A4W7F9

PR
Gene name
hemH
Protein name
Ferrochelatase
Names
Heme synthase, Protoheme ferro-lyase
Species
Enterobacter sp (strain 638)
KEGG Pathway
ent:Ent638_0955
EC number
4.98.1.1: Forming coordination complexes
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-48 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4W7F9

Entry ID Method Resolution Chain Position Source
AF-A4W7F9-F1 Predicted AlphaFoldDB

No variants for A4W7F9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4W7F9

No associated diseases with A4W7F9

3 regional properties for A4W7F9

Type Name Position InterPro Accession
active_site Ferrochelatase, active site 189 - 207 IPR019772
domain Ferrochelatase, C-terminal 170 - 303 IPR033644
domain Ferrochelatase, N-terminal 6 - 165 IPR033659

Functions

Description
EC Number 4.98.1.1 Forming coordination complexes
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ferrochelatase activity Catalysis of the reaction: heme B (protoheme) + H+ = Fe(2+) + protoporphyrin IX.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
heme biosynthetic process The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSQAKTGILL ANLGTPEAPT PAAVKRYLRQ FLSDTRVVDT PRVLWWPLLR GVILPIRSPR
70 80 90 100 110 120
VAKLYQSVWM EEGSPLMVYS RRQEKALAAR LPDMPVALGM SYGKPSLESA VENLLSQDVE
130 140 150 160 170 180
HIVVLALYPQ YSCSTVAAVW DELARILATR RHIPGITFIR DYADDEMYIA ALVNSARASF
190 200 210 220 230 240
AKHGEPDLLL LSYHGIPQRY ADEGDDYPQR CRDTTRELVS ALGLPPEKVM MTFQSRFGRE
250 260 270 280 290 300
PWLTPYTDET LKMLGEKGVK HVQVMSPGFS ADCLETLEEI AVQNREFFLE AGGTKYEYIP
310
ALNDSPEHIE MMVSLVTTRR