A4W4J7

PR
Gene name
mutS
Protein name
DNA mismatch repair protein MutS
Names
Species
Streptococcus suis (strain 98HAH33)
KEGG Pathway
ssv:SSU98_2128
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

756-837 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4W4J7

Entry ID Method Resolution Chain Position Source
AF-A4W4J7-F1 Predicted AlphaFoldDB

No variants for A4W4J7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4W4J7

No associated diseases with A4W4J7

5 regional properties for A4W4J7

Type Name Position InterPro Accession
domain DNA mismatch repair protein MutS, C-terminal 596 - 786 IPR000432
domain DNA mismatch repair protein MutS-like, N-terminal 9 - 119 IPR007695
domain DNA mismatch repair protein MutS, core 257 - 579 IPR007696
domain DNA mismatch repair protein MutS, connector domain 127 - 240 IPR007860
domain DNA mismatch repair protein MutS, clamp 416 - 506 IPR007861

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
damaged DNA binding Binding to damaged DNA.
mismatched DNA binding Binding to a double-stranded DNA region containing one or more mismatches.

1 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMATEKISPG MQQYLDIKAQ YPDAFLLFRM GDFYELFYED AVEAAQILEL SLTSRNKNAE
70 80 90 100 110 120
NPIPMAGVPY HAAQQYIDTL VELGHKVAIA EQMEDPKQAV GVVKREVVQV ITPGTVTDSS
130 140 150 160 170 180
KMGADSNYLV AIDRQGVQFA LSYMDVSTGQ FFVTSLDDFT SLCGEIRNLR ARELVIGYAL
190 200 210 220 230 240
SEEEEQVFSN QMNLLLSFED EVTEDVQLID NSLTDLEKAA AGKLLSYLHR TQMRDLSHLQ
250 260 270 280 290 300
KVVHYEIKDY LQMDYATKSS LDLLENGRTG KKHGSLYWLL DETKTAMGMR LLRTWIDRPL
310 320 330 340 350 360
IDLKRIENRQ AVVQVFLDYF FERSDLVEAL KGVYDIERLA SRVSFGKTMP KDLLQLSQTL
370 380 390 400 410 420
GNIPAIKNIL QQINEPALGN LVAGLDPIPE LHALISSAID PEAQGTITDG NIIRTGFDET
430 440 450 460 470 480
LDQYRLVMRE GAGWIAEIEA KEREASGINN LKIDYNKKDG YYFHVTNSNL GNVPDHFFRK
490 500 510 520 530 540
ATLKNSERYG TEELAKIEGQ MLEARDKSAN LEYEIFMRIR QEVEKYIGRL QKLARTIATI
550 560 570 580 590 600
DVLQAFAVVA EQQHLVCPRF TDQRELTIDR GRHAVVEKVM GKQTYIPNSI HLNTDTHMQL
610 620 630 640 650 660
ITGPNMSGKS TYMRQLAVIV IMAQMGSYVP ADQAELPIFD AIFTRIGAAD DLVSGQSTFM
670 680 690 700 710 720
VEMMEANKAV RLATDRSLIL FDELGRGTAT YDGMALAQSI IEYIHDKIGA KTLFATHYHE
730 740 750 760 770 780
LTDLSQTLEH LENVHVSTLE KDGQVTFLHK IAQGPADKSY GIHVAKIAGM PEELLQRADR
790 800 810 820 830 840
ILQTLENQAP TAPTHPAPSV VEEPSGQLDL FADTPSHPVL DELEKLDIYN MTPMEVMMAV
AELKKKI