A4W428

PR
Gene name
polC
Protein name
DNA polymerase III PolC-type
Names
PolIII
Species
Streptococcus suis (strain 98HAH33)
KEGG Pathway
ssv:SSU98_1959
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

160-252 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4W428

Entry ID Method Resolution Chain Position Source
AF-A4W428-F1 Predicted AlphaFoldDB

No variants for A4W428

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4W428

No associated diseases with A4W428

9 regional properties for A4W428

Type Name Position InterPro Accession
domain Polymerase/histidinol phosphatase, N-terminal 341 - 408 IPR003141
domain PHP domain 342 - 700 IPR004013
domain DNA polymerase III epsilon subunit, exonuclease domain 422 - 642 IPR006054
domain Bacterial DNA polymerase III, alpha subunit, NTPase domain 842 - 1023 IPR011708-1
domain Bacterial DNA polymerase III, alpha subunit, NTPase domain 1039 - 1110 IPR011708-2
domain Exonuclease, RNase T/DNA polymerase III 426 - 592 IPR013520
domain DNA polymerase III PolC-like, N-terminal domain II 92 - 205 IPR024754
domain DNA polymerase III PolC-type, N-terminal domain I 5 - 78 IPR028112
domain DNA polymerase III alpha subunit finger domain 1114 - 1270 IPR040982

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
3'-5' exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.

1 GO annotations of biological process

Name Definition
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDKFQLLLQ QIGMPLDARQ SGAFSTATIE KVVLHKVSKL WEFTFRFETP LPLMDYQLFK
70 80 90 100 110 120
ARLATEFEKV GNKIQFSIVS DAEAFEAGLV EAYYPEAFTE DLCQSAGFKA LFQPLEVAYR
130 140 150 160 170 180
DGVLWIKGPE TIDTDHFRKN HLPNLVEQYK RFGFGNLAVD IQVCQEMTQQ QAEIFHAQNA
190 200 210 220 230 240
EIYQQANEEN LAALEQLAQM APPPEAAQPF VPEYKKNRPA KVNIEKAEIT PMIEVDSEEN
250 260 270 280 290 300
RIVFEGLVFE VEQKTTKTGR VIINFKMTDY TSSFTLQKWA KNEEEAQKFD MVKKGNWLRV
310 320 330 340 350 360
RGNVETNNFT RDLTMNVQEV QEVKKEIRKD LMPEGEKRVE FHAHTNMSTM DALPAVEDLV
370 380 390 400 410 420
ARAAAWGHKA VAITDHGNVQ SFPHGYHAAR KAGIKPLFGM EANIVEDSVP IAYNEADVVL
430 440 450 460 470 480
SDATYVVFDV ETTGLSAVNN ALIQIAASKM HKGNIIAEFD EFIDPGHPLS QFTTDLTGIT
490 500 510 520 530 540
DEHVRGSKPL EQVLREFQDF CQDSVMVAHN ATFDVGFMNV NYERAGLPII SQPVIDTLEF
550 560 570 580 590 600
ARNLYPDFKR HGLGPLTKRF GVALEHHHMA NYDAEATGRL LFIFLKDALE KHNLTNLNQL
610 620 630 640 650 660
NTELIAEDSY KKARVKHATL YVINQVGLKN MFKLVSLSNT KYFEGVPRIP RTVLNAHREG
670 680 690 700 710 720
LILGTACQEG EVFDDLLSKG IDEAVKTAAY YDFIEVMPPA LYAPMIAKEQ FKDMAEIEET
730 740 750 760 770 780
IKQLIEVGRR AGLPVLATGN VHYIDPEEEI YREIIVRALG QGAPINWTIG NGENAQPAPL
790 800 810 820 830 840
PKAHFRTTSE MLDEFAFLGE SLAREIVITN PNAMLDRFED VQVVKTDLYT PYIEKAEETV
850 860 870 880 890 900
AELTYQKAFE IYGNPLPDII DLRIEKELTS ILGNGFAVIY LASQMLVHRS NERGYLVGSR
910 920 930 940 950 960
GSVGSSFVAT MIGITEVNPM PPHYVCPNCQ HSEFITDGSY GSGFDLPDKD CEKCGTKYKK
970 980 990 1000 1010 1020
DGQDIPFETF LGFDGDKVPD IDLNFSGDDQ PSAHLDVRDI FGEENAFRAG TVGTVAAKTA
1030 1040 1050 1060 1070 1080
YGFVRGYERD YGKFYRDVEV ERLAAGAAGV KRTTGQHPGG IIVFPDYMDV YDFTPVQYPA
1090 1100 1110 1120 1130 1140
DDVTASWQTT HFNFHDIDEN VLKLDILGHD DPTMVRKLQD LSGIDPQTIP ADDKGVMALF
1150 1160 1170 1180 1190 1200
SGTEILGVTP EQIGTPTGML GIPEFGTNFV RGMVEETKPT TFSELLQLSG LSHGTDVWLG
1210 1220 1230 1240 1250 1260
NAQDLIKAGI ANLSTVIGCR DDIMVYLMHA GLPPKMAFNI MERVRKGLWL KISEEERNGY
1270 1280 1290 1300 1310 1320
IQAMKDNKVP DWYIESCGKI KYMFPKAHAA AYVMMALRVA YFKVHHPLYY YCAYFSIRAK
1330 1340 1350 1360 1370 1380
AFDLATMSGG LERVKAKMEE IALKKKNNEA SNVEQDLYTT LELVNEMLER GFKFGKLDLY
1390 1400 1410 1420 1430 1440
KSHATDFLIE EDTLIPPFVA MDGLGENVAK QVVAARAEGE FLSKTELRKR GGLSGTLVEK
1450 1460
MDEMGILGKM PEDNQLSLFD DLF