A4W221

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Streptococcus suis (strain 98HAH33)
KEGG Pathway
ssv:SSU98_1252
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

393-472 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4W221

Entry ID Method Resolution Chain Position Source
AF-A4W221-F1 Predicted AlphaFoldDB

No variants for A4W221

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4W221

No associated diseases with A4W221

4 regional properties for A4W221

Type Name Position InterPro Accession
domain DHHA1 domain 736 - 869 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 656 - 699 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 559 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 712 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKNLSSAQIR QMWLDFWKSK GHSVEPSANL VPVNDPTLLW INSGVATLKK YFDGSVIPDN
70 80 90 100 110 120
PRITNAQKSI RTNDIENVGK TARHHTMFEM LGNFSIGDYF RDEAIEWGFE LLTSPEWFAF
130 140 150 160 170 180
PKDKLYMTYY PDDMDSYNRW IALGVEPSHL IPLEDNFWEI GAGPSGPDTE IFFDRGTDFD
190 200 210 220 230 240
PENIGIRLLE EDIENDRYIE IWNIVLSQFN ADPAVPRSEY KELPNKNIDT GAGLERLAAI
250 260 270 280 290 300
FQGAKTNFET DLFLPIIREV EKISGKTYDQ DGDNMSFKVI ADHIRALSFA IGDGALPGNE
310 320 330 340 350 360
GRGYVLRRLL RRASMHGQRL GITEPFLYKL VETVGNIMES YYPEVLEKRA FIEKIVKSEE
370 380 390 400 410 420
ESFARTIHTG SQFAEQLMDK LAAEGKSEID GRDIFKLYDT YGFQVELTEE LAEHRGMTLD
430 440 450 460 470 480
IAGFEAAMKE QQDRARASVV KGGSMGMQNE TLAAITEEST FVYGQTALEA SLSVIVADNA
490 500 510 520 530 540
RTEAVSEGQA LLVFDQTPFY AEMGGQVADH GFVKNATGDI VATVIDVQKA PNGQPLHTVE
550 560 570 580 590 600
LSASISVGQT YTLEIETKRR KGVEKNHTAT HLLHAALHNI IGEHATQAGS LNEQDFLRFD
610 620 630 640 650 660
FTHFEAVTAE ELRRIEEEVN EQIWNAIPVV TVETDIDTAK EMGAMALFGE KYGKEVRVVT
670 680 690 700 710 720
IGDYSVELCG GTHVGNTAEI GIFKILKEEG IGSGTRRIIA VTGREAFLAY RDQEDALKEV
730 740 750 760 770 780
AATIKSPQIK EVPNKVESLA QQVRDLQKEN AALKEKAAAA AAGDVFKNVK DANGIRYIAS
790 800 810 820 830 840
QVQVSDAGAL RTFADNWKQK DYSDVLVLVA AIGDKVNVLV ASKSSDVHAG NLIKVLAPIV
850 860 870
AGRGGGKPDM AMAGGSDASA IQTLLNSVAN NL