A4VYU4

PR
Gene name
rpoC
Protein name
DNA-directed RNA polymerase subunit beta'
Names
RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'
Species
Streptococcus suis (strain 98HAH33)
KEGG Pathway
ssv:SSU98_0123
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

276-349 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4VYU4

Entry ID Method Resolution Chain Position Source
AF-A4VYU4-F1 Predicted AlphaFoldDB

No variants for A4VYU4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4VYU4

No associated diseases with A4VYU4

6 regional properties for A4VYU4

Type Name Position InterPro Accession
domain RNA polymerase, alpha subunit 334 - 475 IPR000722
domain RNA polymerase, N-terminal 225 - 504 IPR006592
domain RNA polymerase Rpb1, domain 3 479 - 663 IPR007066
domain RNA polymerase Rpb1, domain 1 5 - 332 IPR007080
domain RNA polymerase Rpb1, domain 5 770 - 1131 IPR007081
domain RNA polymerase Rpb1, domain 4 692 - 759 IPR007083

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
magnesium ion binding Binding to a magnesium (Mg) ion.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVDVNRFKSM QITLASPSKV RSWSYGEVKK PETINYRTLK PERDGLFDEV IFGPTKDWEC
70 80 90 100 110 120
SCGKYKRIRY KGITCDRCGV EVTRAKVRRE RMGHIELKAP ISHIWYFKGI PSRMGLTLDM
130 140 150 160 170 180
SPRALEEVIY FAAYVVIDPK DTPLEHKSIM TEREYRERLR EYGYGSFVAK MGAEAIQDLL
190 200 210 220 230 240
KQVDLPKEIA ALKEELKTAS GQKRIKAVRR LDVLDAFYKS GNKPEWMILN ILPVIPPDLR
250 260 270 280 290 300
PMVQLDGGRF AASDLNELYR RVINRNNRLA RLLELNAPGI IVQNEKRMLQ EAVDALIDNG
310 320 330 340 350 360
RRGRPITGPG SRPLKSLSHM LKGKQGRFRQ NLLGKRVDFS GRSVIAVGPT LKMYQCGVPR
370 380 390 400 410 420
EMAIELFKPF VMREIVARDI AGNVKAAKRL IERGDDRIWD ILEEVIKEHP VLLNRAPTLH
430 440 450 460 470 480
RLGIQAFEPV LIDGKALRLH PLVCEAYNAD FDGDQMAIHV PLSEEAQAEA RILMLAAEHI
490 500 510 520 530 540
LNPKDGKPVV TPSQDMVLGN YYLTMEDAGR EGEGMVFKDA DEAVMAYRNG YVHLHTRVGI
550 560 570 580 590 600
ATDSLDKPWK DNQKHKVMMT TVGKILFNAI MPEGLPYLQE PNNANLTEGT PDKYFLEPGS
610 620 630 640 650 660
DIKAAIAELP INPPFKKKNL GNIIAEIFKR FRTTETSALL DRLKDLGYYH STLAGLTVGI
670 680 690 700 710 720
ADIPVIDNKA EIIEESHERV EQIKKQFRRG MITDDERYAA VTDEWRSAKE KLEKRLVEKQ
730 740 750 760 770 780
DPKNPIVMMM DSGARGNISN FSQLAGMRGL MSAPNGRIME LPILSNFREG LSVLEMFFST
790 800 810 820 830 840
HGARKGMTDT ALKTADSGYL TRRLVDVAQD VIIREDDCGT DRGLDIRSIT DGKEMIEPLE
850 860 870 880 890 900
ERLQGRYTKK TVKHPETGAV IIGPNQLITE DIAREIVNAG VEQVTIRSVF TCNTRHGVCR
910 920 930 940 950 960
HCYGINLATG DAVEVGEAVG TIAAQSIGEP GTQLTMRTFH TGGVASNSDI TQGLPRVQEI
970 980 990 1000 1010 1020
FEARNPKGEA VITEVKGEVI AIEEDASTRT KKVFVKGKTG EGEYVVPFTA RMKVEVGDQV
1030 1040 1050 1060 1070 1080
ARGAALTEGS IQPKRLLEVR DVLAVETYLL SEVQKVYRSQ GVEIGDKHIE VMVRQMLRKV
1090 1100 1110 1120 1130 1140
RVMDPGDTDL LMGTLMDITD FTDANAEVVI AGGIPATARP VLMGITKASL ETNSFLSAAS
1150 1160 1170 1180 1190 1200
FQETTRVLTD AAIRGKRDNL LGLKENVIIG KIIPAGTGMA RYRNLEPQAI NEVEIIEDTV
1210
AEELAAEAEL EAVTE