A4VNE5

PR
Gene name
metE
Protein name
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
Names
Cobalamin-independent methionine synthase, Methionine synthase, vitamin-B12 independent isozyme
Species
Pseudomonas stutzeri (strain A1501)
KEGG Pathway
psa:PST_2850
EC number
2.1.1.14: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

344-469 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4VNE5

Entry ID Method Resolution Chain Position Source
AF-A4VNE5-F1 Predicted AlphaFoldDB

No variants for A4VNE5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4VNE5

No associated diseases with A4VNE5

3 regional properties for A4VNE5

Type Name Position InterPro Accession
domain Histidine kinase/HSP90-like ATPase 31 - 188 IPR003594
conserved_site Heat shock protein Hsp90, conserved site 29 - 38 IPR019805
domain Heat shock protein Hsp90, N-terminal 9 - 212 IPR020575

Functions

Description
EC Number 2.1.1.14 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate.
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
methylation The process in which a methyl group is covalently attached to a molecule.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAVAHNLGFP RIGADRELKK ALEAYWKGEL DEQGLRQVGR QLRARHWQAQ LDAGIELLPV
70 80 90 100 110 120
GDFAWYDQVL SHSLMFGVIP QRFRPAEGQA TLDTLFAMAR GVARSCCGGA QAQEMTKWFD
130 140 150 160 170 180
TNYHYLVPEF SVDQQFQLSW TQLFEEVEEA KALGHAIKPV LIGPLSYLWL GKLKGEADQT
190 200 210 220 230 240
QTFDKLELLD RLLPVYGEVL DRLAAQGVEW VQIDEPILAL DLPQDWKNAF ERAYNLLQRA
250 260 270 280 290 300
PLKKLVATYF GGLEDNLGLA ATLPVDGLHI DLVRAPEQYP VILDRLPAYK VLSLGLVNGR
310 320 330 340 350 360
NVWRCDLDKA LEVARHAAER LGERLWLAPS CSLLHSPVDL EREDRLDEEV KSWLAFAVQK
370 380 390 400 410 420
CSEVATLARA IDDPQDAEVQ AALARSRAVQ AARAQSPRIH KPAVQARLAA IEAKDSRRTS
430 440 450 460 470 480
VFATRIELQR ARLQLPAFPT TTIGSFPQTP AIRLARQAYK QGRLSLGDYT EAMQAEIRHA
490 500 510 520 530 540
VAVQEQIGLD VLVHGEAERN DMVEYFAEQL EGYVFTRFGW VQSYGSRCVK PAIIYGDLSR
550 560 570 580 590 600
PRPMTVDWIR YAQQQTDRIM KGMLTGPVTM LMWSFAREDV PREVQARQLA LAIRDEVCDL
610 620 630 640 650 660
EAAGIRIIQI DEAAFREGLP LRREQWRHYL DWAVEAFRLC ASGVRDETQI HTHMCYSEFN
670 680 690 700 710 720
DVIESIAAMD ADVITIETSR SQMELLEAFR AFDYPNDIGP GVYDIHSPRV PDTAEMVQLL
730 740 750 760 770
EKAAECIPAE RLWVNPDCGL KTRGWPETEA ALVNMVAAAR QLRAARSAKV A