A4VJ35

PR
Gene name
cobB
Protein name
Hydrogenobyrinate a,c-diamide synthase
Names
Hydrogenobyrinic acid a,c-diamide synthase
Species
Pseudomonas stutzeri (strain A1501)
KEGG Pathway
psa:PST_1292
EC number
6.3.5.9: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4VJ35

Entry ID Method Resolution Chain Position Source
AF-A4VJ35-F1 Predicted AlphaFoldDB

No variants for A4VJ35

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4VJ35

No associated diseases with A4VJ35

2 regional properties for A4VJ35

Type Name Position InterPro Accession
domain CobQ/CobB/MinD/ParA nucleotide binding domain 9 - 187 IPR002586
domain CobB/CobQ-like glutamine amidotransferase 239 - 418 IPR011698

Functions

Description
EC Number 6.3.5.9 Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cobyrinic acid a,c-diamide synthase activity Catalysis of the conversion of cobyrinic acid to cobyrinic acid a,c-diamide via the intermediate formation of cobyrinic acid c-monoamide.
hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity Catalysis of the reaction: 2 L-glutamine + 2 ATP + 2 H(2)O + hydrogenobyrinate = 2 L-glutamate + 2 ADP + 4 H(+) + hydrogenobyrinate a,c-diamide + 2 phosphate.

2 GO annotations of biological process

Name Definition
cobalamin biosynthetic process The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTSRNCPALL IAAPASGQGK TTVTAALARL HARQGKRVRV FKCGPDFLDP MILARASGKP
70 80 90 100 110 120
VYQLDLWMVG EEESRRLLWE AAGEADLILI EGVMGLFDGA PSAADLARRF GVPVLAVIDG
130 140 150 160 170 180
SAMAQTFGAL AHGLKSFQPE LPFAGVLANR VGSTRHGEIL RDSLPESIRW YGALPRSVDM
190 200 210 220 230 240
ELPSRHLGLV QAEELADLDA RLDAAADALA QSAETELPPA VSFAAPTRVS LAPLLAGVRI
250 260 270 280 290 300
GVARDAAFAF LYQANLDLLQ ALGAELLFFS PLRFARLPAV DSLYLPGGYP ELHLRALSRN
310 320 330 340 350 360
GPMAEAIRAH HAAGKPILAE CGGMLYLLDG LTDRGDERAE MLGLLPGEAR MQQRLSALAL
370 380 390 400 410 420
QEVELPEGRL RGHTFHHSML ESPLQPLARG ECPNYKRTAE AVYRSGRLTA SYIHFYLPSD
PLAAAALLRP