A4THK0

PR
Gene name
mtgA
Protein name
Biosynthetic peptidoglycan transglycosylase
Names
Glycan polymerase, Peptidoglycan glycosyltransferase MtgA, PGT
Species
Yersinia pestis (strain Pestoides F)
KEGG Pathway
ypp:YPDSF_0345
EC number
2.4.1.129: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

72-145 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4THK0

Entry ID Method Resolution Chain Position Source
AF-A4THK0-F1 Predicted AlphaFoldDB

No variants for A4THK0

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4THK0

No associated diseases with A4THK0

1 regional properties for A4THK0

Type Name Position InterPro Accession
domain Glycosyl transferase, family 51 60 - 227 IPR001264

Functions

Description
EC Number 2.4.1.129 Hexosyltransferases
Subcellular Localization
  • Cell inner membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
peptidoglycan-based cell wall A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
pentosyltransferase activity Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor).
peptidoglycan glycosyltransferase activity Catalysis of the reaction: [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphosphoundecaprenol + GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.

3 GO annotations of biological process

Name Definition
cell wall organization A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis.
peptidoglycan biosynthetic process The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls.
regulation of cell shape Any process that modulates the surface configuration of a cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MISVRRGFSQ LWYWGKRGVI GIIALWMAGI LIFAFLPVPF SMVMIERQLG AWLTGDFAYV
70 80 90 100 110 120
AHSDWVPMDE ISPYMALAVM AAEDQKFPDH WGFDVGAIES ALSHNQRNQK RIRGASTLSQ
130 140 150 160 170 180
QTAKNVFLWD GRSWVRKGLE VGLTAGIELI WTKRRILTVY LNIAEFGNGI FGVEAAARHF
190 200 210 220 230 240
FNKPASKLSA SEAALLAAVL PNPLRFKVNA PSGYVISRQQ WILRQMHQLG GKTFLQENTL
D