A4TE12

PR
Gene name
leuB
Protein name
3-isopropylmalate dehydrogenase
Names
3-IPM-DH, Beta-IPM dehydrogenase, IMDH
Species
Mycolicibacterium gilvum (strain PYR-GCK) (Mycobacterium gilvum (strain PYR-GCK))
KEGG Pathway
mgi:Mflv_4233
EC number
1.1.1.85: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

228-336 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4TE12

Entry ID Method Resolution Chain Position Source
AF-A4TE12-F1 Predicted AlphaFoldDB

No variants for A4TE12

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4TE12

No associated diseases with A4TE12

5 regional properties for A4TE12

Type Name Position InterPro Accession
domain Pyruvate carboxyltransferase 33 - 313 IPR000891
conserved_site Alpha-isopropylmalate/homocitrate synthase, conserved site 40 - 56 IPR002034-1
conserved_site Alpha-isopropylmalate/homocitrate synthase, conserved site 243 - 256 IPR002034-2
domain 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain 422 - 551 IPR013709
domain LeuA, N-terminal catalytic TIM barrel domain 32 - 315 IPR039371

Functions

Description
EC Number 1.1.1.85 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
3-isopropylmalate dehydrogenase activity Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+.
magnesium ion binding Binding to a magnesium (Mg) ion.
NAD binding Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.

1 GO annotations of biological process

Name Definition
leucine biosynthetic process The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKLAVIAGDG IGPEVIGEAL RVLDAVVPGV EKTEYDLGAR LYHRTGEVLP DSVLDELKGH
70 80 90 100 110 120
DAILLGAIGD PSMPSGVLER GLLLRIRFEL DHHINLRPGR LYPGVQSPLA GNPEIDFVVV
130 140 150 160 170 180
REGTEGPYTG NGGAIRVGTP HEIATEVSVN TAYGVRRVVQ DAFKRAQQRR KHLTLVHKNN
190 200 210 220 230 240
VLTNAGSLWW RTVQAVAAEY PEVEVAYQHV DAATIHMVTD PGRFDVIVTD NLFGDIITDL
250 260 270 280 290 300
AAAVCGGIGL AASGNIDATL TNPSMFEPVH GSAPDIAGQG IADPTAAIMS VSLLLAHMAE
310 320 330
IDAAARVDKA VAEHLATRGD EKLSTTQVGD RILGKL