A4SZL8

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Polynucleobacter asymbioticus (strain DSM 18221 / CIP 109841 / QLW-P1DMWA-1) (Polynucleobacter necessarius subsp. asymbioticus)
KEGG Pathway
pnu:Pnuc_1719
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

394-471 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4SZL8

Entry ID Method Resolution Chain Position Source
AF-A4SZL8-F1 Predicted AlphaFoldDB

No variants for A4SZL8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4SZL8

No associated diseases with A4SZL8

4 regional properties for A4SZL8

Type Name Position InterPro Accession
domain DHHA1 domain 732 - 871 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 654 - 696 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 5 - 554 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 1 - 709 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKVTQIRQAY LDFFAQKGHQ IVPSSPVVPG DDPTLLFTNA GMNQFKDVFL GFDKRSYTRA
70 80 90 100 110 120
TTAQKCIRAG GKHNDLDNVG YTARHHTFFE MLGNFSFGDY FKKDAIQFAW DLLTQVFELP
130 140 150 160 170 180
KDKLLVTVYA EDDEAYAIWK DQIGVPAERI IRIGDNKGAR YASDNFWMMG DTGPCGPCTE
190 200 210 220 230 240
IFYDHGEHIP GGPPGSPDED GDRFIEIWNN VFMQFNRDEA GVMHPLPKPS VDTGMGLERI
250 260 270 280 290 300
AAVLQHVHSN YEIDLFVNLI KAAKDTVDGA GGENCDAQSP SLKVIADHIR ACSFIVVDGV
310 320 330 340 350 360
IPGNAGRGYV LRRIARRAIR HGYKLGARKP FFYQLVPALV KEMGDAYPEL RAAQDKVSEV
370 380 390 400 410 420
LKQEEERFFQ TIANGMEILD GALAGGAKVV DGETAFRLHD TFGFPLDLTA DVCRERGVTV
430 440 450 460 470 480
DSEGFEVAMQ KQRDQARAAG KFKVAQGLDY KGVPTRFHGY ETLKHEGAKI TALYLDGSAV
490 500 510 520 530 540
NSVKAGDAAV VVLDNTPFYA ESGGQVGDKG ELRNEAARFT VDDTFKIQAD VFGHQGEVLE
550 560 570 580 590 600
GELKVGDTLN ALVDIALRND TMRNHSATHI LHKALREVLG DHVQQKGSLV DASKTRFDFT
610 620 630 640 650 660
HNAPITAEQI RRIEDIVNAE ILDNSATSGK VMSLEDAQKT GAMMLFGEKY GDEVRVLEIG
670 680 690 700 710 720
SSKELCGGTH VSRTGDIGSL KIVSEGGVAA GIRRVEAVTG QNALHFLQGL EDKINEAATI
730 740 750 760 770 780
LKTHPGDLVN RVAQLQESLR LAERELEKVN SKLAASQGDE LAGQAIDVNG LKVLAARLDG
790 800 810 820 830 840
ADAGVLRETM DALKAKLKTA AIVLASVQGD KVSLIAGVTA DSIAKVKAGD LVNFVAQQVG
850 860 870
GKGGGKPEMA MAGGNDPSKL GAALDGVKDW VASK