A4SWP6

PR
Gene name
serS
Protein name
Serine--tRNA ligase
Names
Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase
Species
Polynucleobacter asymbioticus (strain DSM 18221 / CIP 109841 / QLW-P1DMWA-1) (Polynucleobacter necessarius subsp. asymbioticus)
KEGG Pathway
pnu:Pnuc_0692
EC number
6.1.1.11: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

4-152 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4SWP6

Entry ID Method Resolution Chain Position Source
AF-A4SWP6-F1 Predicted AlphaFoldDB

No variants for A4SWP6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4SWP6

No associated diseases with A4SWP6

4 regional properties for A4SWP6

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 234 - 409 IPR002314
domain Aminoacyl-tRNA synthetase, class II 170 - 420 IPR006195
domain Serine-tRNA synthetase, type1, N-terminal 1 - 107 IPR015866
domain Serine-tRNA ligase catalytic core domain 119 - 427 IPR033729

Functions

Description
EC Number 6.1.1.11 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
serine-tRNA ligase activity Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser).

3 GO annotations of biological process

Name Definition
selenocysteine biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins.
selenocysteinyl-tRNA(Sec) biosynthetic process The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA
seryl-tRNA aminoacylation The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIDPQLLRKD IAAVQARLAT RKFQLDVEKF NTLESERKSL QTRTEELQAK RNQLAKAIGM
70 80 90 100 110 120
KKGKGEDAAA EMAEASQINV DMESGAARLS VLQAEIADFL MGIPNLPDES VPAGKDETEN
130 140 150 160 170 180
KEVKVWGEQP MFDFEIKDHV DLGGPLGLDF EVAAKISGSR FVVLKGPIAR LHRALAQFMI
190 200 210 220 230 240
DTHATHHGYQ EVYAPYMVNA ASMRGTGQLP KFEEDLFKVP RQMGGEDEGG EAKTENFYLI
250 260 270 280 290 300
PTAEVPVTNL VRDEIVNADT LPLKFVAHTP CFRSEAGSYG RDVRGMIRQH QFDKVELVQI
310 320 330 340 350 360
TKPEHSMQAL EELTGHAERI LELLELPYRK VLLCTGDMGF GSTKTYDLEV WVPSQNAYRE
370 380 390 400 410 420
ISSCSSMGDF QARRMQARFK AGQGKPELLH TLNGSGLAVG RALVALIENK QLVDGSIAIP
430
KALQPYLGGL ETLKPN