A4SWK9

PR
Gene name
argH
Protein name
Argininosuccinate lyase
Names
ASAL, Arginosuccinase
Species
Polynucleobacter asymbioticus (strain DSM 18221 / CIP 109841 / QLW-P1DMWA-1) (Polynucleobacter necessarius subsp. asymbioticus)
KEGG Pathway
pnu:Pnuc_0655
EC number
4.3.2.1: Lyases acting on amides, amidines, etc
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-46 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4SWK9

Entry ID Method Resolution Chain Position Source
AF-A4SWK9-F1 Predicted AlphaFoldDB

No variants for A4SWK9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4SWK9

No associated diseases with A4SWK9

3 regional properties for A4SWK9

Type Name Position InterPro Accession
conserved_site Fumarate lyase, conserved site 286 - 295 IPR020557
domain Fumarate lyase, N-terminal 18 - 311 IPR022761
domain Argininosuccinate lyase, C-terminal 374 - 448 IPR029419

Functions

Description
EC Number 4.3.2.1 Lyases acting on amides, amidines, etc
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
argininosuccinate lyase activity Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine.

1 GO annotations of biological process

Name Definition
arginine biosynthetic process via ornithine The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSSKNSLAN KAQAWSARFT EPVDELVQRY TASIGFDQRF AMVDIAGSLA HAEMLATQKI
70 80 90 100 110 120
ISAQDLADIQ KGMAQIKSEI EAGQFEWQLA LEDVHLNIEA RLTQLVGDAG KRLHTGRSRN
130 140 150 160 170 180
DQVATDLRLW LRASVDDISV TLKSLRIALL DLAEKHASTI MPGHTHLQVA QPITFGHHLM
190 200 210 220 230 240
AYYEMFSRDA SRLVDLRARF NRLPLGAAAL AGTTYPIDRE QVARILGFDG ICNNSLDAVS
250 260 270 280 290 300
DRDFAIEFCA FSSILMMHVS RLSEELVLWL SPRFGFIDLP DRFCTGSSIM PQKKNPDVPE
310 320 330 340 350 360
LARGKTGRVY GDLISLLTLM KSQPLAYNKD NQEDKEPLFD AVDTVQDTLR IFADMVPHIE
370 380 390 400 410 420
VKAEVMKAAA EEGFATATDL ADYLVKKGLA FRDAHEAVAH AVKACVGRNC MLTDLSLAEL
430 440 450 460 470
RFACGLDNRP ELMSDDVFAL LTVDGSVQSR QHAGGTAPAQ VLAAIKRART DL