A4SIX5

PR
Gene name
ileS
Protein name
Isoleucine--tRNA ligase
Names
Isoleucyl-tRNA synthetase, IleRS
Species
Aeromonas salmonicida (strain A449)
KEGG Pathway
asa:ASA_0684
EC number
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-47 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4SIX5

Entry ID Method Resolution Chain Position Source
AF-A4SIX5-F1 Predicted AlphaFoldDB

No variants for A4SIX5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4SIX5

No associated diseases with A4SIX5

5 regional properties for A4SIX5

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 58 - 69 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 28 - 656 IPR002300
domain Zinc finger, FPG/IleRS-type 915 - 941 IPR010663
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 701 - 855 IPR013155
domain Isoleucyl tRNA synthetase type 1, anticodon-binding domain 656 - 836 IPR033708

Functions

Description
EC Number 6.1.1.5 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSDYKHTLNL PETEFPMRGD LAKREPNMLK RWYDQDLYGA IRRAKAGKPS FILHDGPPYA
70 80 90 100 110 120
NGSIHIGHSV NKILKDVIIK SKGLSGFDSP YVPGWDCHGL PIELKVEGMV GKPGEKVSAA
130 140 150 160 170 180
EFRAECRKYA KTQIEAQKTD FIRLGVLGDW EHPYLTMDFG TEANIIRSMA KIVENGHLHK
190 200 210 220 230 240
GSKPVHWCTD CGSALAEAEV EYYDKNSPSI DVRFKAVDEA TVAAKFDCPE GHLGKGPISA
250 260 270 280 290 300
VIWTTTPWTL PANRAIAMHA DLDYALVQVE GEHPERLILA AELVKDVMDR AGIEKFHNLG
310 320 330 340 350 360
YTKGVALELL RFNHPFYSFD VPVVLGDHVT LDAGTGAVHT APGHGQEDFV VGQKYGLEVA
370 380 390 400 410 420
NPVGSNGVYL PDTELFAGQH VFKANAAVVE VLTERGALLH HMVFNHSYPH CWRHKTPIIF
430 440 450 460 470 480
RATPQWFISM EQKGLRQRAL EEIERIEKDG ITQHGQSGWV PAWGKNRIQA MVENRPDWCI
490 500 510 520 530 540
SRQRTWGVPI SLFVHKETQQ LHPESVRLMH EVAKRVEQSG IQAWWDLDKA ELLGSDADMY
550 560 570 580 590 600
DKVPDTLDVW FDSGSTHSSV VDARPEFNGH SADLYLEGSD QHRGWFMSSL MIGVAMKDKA
610 620 630 640 650 660
PYNQVLTHGF TVDGQGRKMS KSIGNVVSPQ DVMNKLGADI LRLWVASTDY TGEMTVSDEI
670 680 690 700 710 720
LKRSADAYRR IRNTARFLLA NLNGFNPATD MVAAADMVVV DRWAVGRAKA AQAEIVTAFE
730 740 750 760 770 780
EYNFHGVTQK LMQFCSIEMG SFYLDVIKDR QYTAKADSLA RRSCQTALYH IAQAMVRWMA
790 800 810 820 830 840
PIMSFTADEI WALLPGERSE FVFTEEWYDG LFGLDAGEQM DDAFWAEILT VRGEVNKALE
850 860 870 880 890 900
AARGEKRIGG SLQAELTLFA KPELAERLNA LADELRFVLL TSKAKVVTAD TAPEGSVATE
910 920 930 940 950
RADLWLSVAQ SAAAKCDRCW HHVEDVGTIA GHEEICGRCA TNVEGDGETR QFA