A4RZ86

PR
Gene name
LIP1
Protein name
Lipoyl synthase, mitochondrial
Names
Lipoate synthase, LS, Lip-syn, Lipoic acid synthase
Species
Ostreococcus lucimarinus (strain CCE9901)
KEGG Pathway
olu:OSTLU_32294
EC number
2.8.1.8: Sulfurtransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-145 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4RZ86

Entry ID Method Resolution Chain Position Source
AF-A4RZ86-F1 Predicted AlphaFoldDB

No variants for A4RZ86

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4RZ86

No associated diseases with A4RZ86

3 regional properties for A4RZ86

Type Name Position InterPro Accession
domain Elp3/MiaA/NifB-like, radical SAM core domain 152 - 360 IPR006638
domain Radical SAM 93 - 385 IPR007197
domain Lipoyl synthase, N-terminal 52 - 136 IPR031691

Functions

Description
EC Number 2.8.1.8 Sulfurtransferases
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
lipoate synthase activity Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
protein lipoylation The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRAVLELTRR RARNARFARA RAVVGARARA ADAQELRDDS KGGSSVDKAT STAAEARETA
70 80 90 100 110 120
HTLEGFREAL RHGPGFDDFV RGDVAYSVPA PKSLKDKTTR KPAWLKREVP GGERYTEIKS
130 140 150 160 170 180
KLRELKLATV CEEAKCPNLG ECWGGGDGKT ATATIMIMGD TCTRGCRFCA VKTAKAPPPL
190 200 210 220 230 240
DKDEPANVSK AIAAWGLDYV VLTSVDRDDI EDQGAGHFRE TVQRLKASCD VLVEALTPDF
250 260 270 280 290 300
RGEKHLVELV ATSGLDVFAH NVETVPELQR DVRDRRANWD QSIEVLKHAK KSGAKITKTS
310 320 330 340 350 360
IMLGLGETHE QVVNALKLLR EADVDVVTFG QYMRPTKKHL AVVEYVTPEA FKRYQEIAEE
370 380 390
MGFLYVASGA MVRSSYKAGE FFLANVIKQR KAKEAAAAN