Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

Autoinhibited structure

Activated structure

1 structures for A4RGD1

Entry ID Method Resolution Chain Position Source
AF-A4RGD1-F1 Predicted AlphaFoldDB

No variants for A4RGD1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4RGD1

No associated diseases with A4RGD1

6 regional properties for A4RGD1

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 258 - 266 IPR000629
domain Helicase, C-terminal 336 - 486 IPR001650
domain DEAD/DEAH box helicase domain 134 - 300 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 129 - 328 IPR014001
domain RNA helicase, DEAD-box type, Q motif 110 - 138 IPR014014
domain DDX47/Rrp3, DEAD-box helicase domain 111 - 313 IPR044765

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

1 GO annotations of biological process

Name Definition
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSAKRVKLS HSKAPGPFRK PSSGDRAAAK VLTKKITQAP KAAAPIKQKA REAEEDDDDD
70 80 90 100 110 120
DKDDKDEEDE EQNDDSSDEA SENDDSTPTV EEATKEGQTE LPSKEETPTK SFRDLGIVEP
130 140 150 160 170 180
LCEACEALKF KKPTPIQEQA IPLALQGRDV IGIAETGSGK TAAFALPILQ SLLEKPQPLF
190 200 210 220 230 240
GLVLAPTREL AAQIGQTFEA LGASISLRCA VVVGGLDMVS QSTALGKKPH IVVATPGRLL
250 260 270 280 290 300
DHLEKTKGFS LRSLKFLVMD EADRLLDLDF GPILDKILKF LPRERRTFLF SATMSSKVES
310 320 330 340 350 360
LQRASLRDPL KVSVSSSQEK TVSTLIQNPL FIPHKHKDVY LIYLANEFAG KTTIVFTRTV
370 380 390 400 410 420
NEAQRVSILL RTLSFGAIPL HGQLSQSMRL GALNKFKARS RDILVATDVA ARGLDIPEVD
430 440 450 460 470 480
LVINFDMPQD SMTYIHRVGR TARAGRSGRA ISIITQYDLE LWLRIEKAAL NGRKLPLFQP
490 500 510 520 530
DKEEVMVFKE RVEEAQRHAR EEMKALHEDR GKKGAVLKGR KRGSATKRRH DDMDAEEG