A4QPH2

PR
Gene name
PI4KAP2
Protein name
Putative phosphatidylinositol 4-kinase alpha-like protein P2
Names
Species
Homo sapiens (Human)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-114 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

462-484 (Activation loop from InterPro)

Target domain

275-589 (Phosphatidylinositol 3-/4-kinase, catalytic domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for A4QPH2

Entry ID Method Resolution Chain Position Source
AF-A4QPH2-F1 Predicted AlphaFoldDB

1 variants for A4QPH2

Variant ID(s) Position Change Description Diseaes Association Provenance
rs2930770
VAR_039391
 223 E>Q No UniProt
dbSNP

No associated diseases with A4QPH2

4 regional properties for A4QPH2

Type Name Position InterPro Accession
domain Phosphatidylinositol 3-/4-kinase, catalytic domain 535 - 814 IPR000403
domain Phosphoinositide 3-kinase, accessory (PIK) domain 52 - 242 IPR001263
conserved_site Phosphatidylinositol 3/4-kinase, conserved site 563 - 577 IPR018936-1
conserved_site Phosphatidylinositol 3/4-kinase, conserved site 656 - 676 IPR018936-2

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
1-phosphatidylinositol 4-kinase activity Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+).
phosphatidylinositol kinase activity Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate.

3 GO annotations of biological process

Name Definition
phosphatidylinositol phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate.
phosphatidylinositol-mediated signaling The series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTVEQKFGLF SAEIKEADPL AASEASQPKP CPPEVTPHYI WIDFLVQRFE IAKYCSSDQV
70 80 90 100 110 120
EIFSSLLQRS MSLNIGRAKG SMNRHVAAIG PRFKLLTLGL SLLHADVVPN ATIRNVLREK
130 140 150 160 170 180
IYSTAFDYFS CPPKFPTQGE KRLREDISIM IKFWTAMFSD KKYLTASQLV PPADIGDLLE
190 200 210 220 230 240
QLVEENTGSL SGPAKDFYQR GFDFFNKITN VSAVIKPYPK GDERKKACLS ALSEVTVQPG
250 260 270 280 290 300
CSLPSNPEAI VLDVDYKSGT PMQSAAKAPY LAKFKVKRCG VSELEKEGLR CRSDSEDECS
310 320 330 340 350 360
TQEADGQKIS WQAAIFKLGD DCRQKSYWGA RMPTDRILRL PASQDMLALQ IIDLFKNIFQ
370 380 390 400 410 420
LVGLDLFVFP YRVVATAPGC GVIECIPDCT SRDQLGRQTD FGMYDYFTRQ YGDESTLAFQ
430 440 450 460 470 480
QARYNFIRSM AAYSLLLFLL QIKDRHNGNI MLDKKGHIIH IDFGFMFESS PGGNLGWEPD
490 500 510 520 530 540
IKLTDEMVMI MGGKMEATPF KWFMEMCVQA TWLCGEPGPY MDVVVSLVTI MLDTGLPCFR
550 560 570 580 590
GQTIKLLKHR FSPNMTEREA ANFIMKVIQS CFLSNRSRTY NMIQYYQNDI PY