A4J104
Gene name |
rpoC |
Protein name |
DNA-directed RNA polymerase subunit beta' |
Names |
RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta' |
Species |
Desulforamulus reducens (strain ATCC BAA-1160 / DSM 100696 / MI-1) (Desulfotomaculum reducens) |
KEGG Pathway |
drm:Dred_0208 |
EC number |
2.7.7.6: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A4J104
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A4J104-F1 | Predicted | AlphaFoldDB |
No variants for A4J104
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A4J104 | |||||
No associated diseases with A4J104
6 regional properties for A4J104
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | RNA polymerase, alpha subunit | 333 - 474 | IPR000722 |
| domain | RNA polymerase, N-terminal | 224 - 503 | IPR006592 |
| domain | RNA polymerase Rpb1, domain 3 | 478 - 619 | IPR007066 |
| domain | RNA polymerase Rpb1, domain 1 | 5 - 331 | IPR007080 |
| domain | RNA polymerase Rpb1, domain 5 | 726 - 1089 | IPR007081 |
| domain | RNA polymerase Rpb1, domain 4 | 648 - 715 | IPR007083 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.6 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| DNA-directed RNA polymerase complex | A protein complex that possesses DNA-directed RNA polymerase activity. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-directed 5'-3' RNA polymerase activity | Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. |
| magnesium ion binding | Binding to a magnesium (Mg) ion. |
| zinc ion binding | Binding to a zinc ion (Zn). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA-templated transcription | The synthesis of an RNA transcript from a DNA template. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLELNNFDSI | RIGLASPDKI | RQWSSGEVKK | PETINYRTLK | PERDGLFCER | IFGPTRDWEC |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HCGKYKRVRY | KGVVCDRCGV | EVTRSKVRRE | RLGHIELAAP | VSHIWYFKGI | PSRMGLLLDM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SPRALEKVLY | FVSYIVIEPG | DTPLLKKQLL | TETEYREYRD | KFGNNFKAGM | GAEAIKVLLV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EINLEELARE | LRQELKEVSG | QRKIRAIRRL | EVVEAFKKSG | NRPEWMIMDV | VPVIPPELRP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MVQLDGGRFA | TSDLNDLYRR | VINRNNRLKR | LLDLGAPDII | VRNEKRMLQE | AVDALIDNGR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RGRPVTGPGN | RPLKSLSDML | KGKQGRFRQN | LLGKRVDYSG | RSVIVVGPRL | KMHQCGLPKE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MALELFKPFV | MKKLVNDGHA | HNIKSAKRMV | ERVRPEVWDV | LEDVIKEHPV | MLNRAPTLHR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LGIQAFEPVL | VEGRAIKIHP | MVCTAYNADF | DGDQMAVHVP | LSAEAQAEAR | LLMLAANNIL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NPKDGKPVAS | PTQDMVLGSY | YLTMDRDGDL | GEGLIFKDEQ | EAMLAYDNKQ | VSLQAKITVR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RKNGERLQTT | VGRIIFNEVI | PEELGYINKV | CDKKTLSKIV | ADCYRRLGNA | HTAELLDGIK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ELGYKYSTRA | GITIGVPDIT | IPEAKKEILA | KAEEQVNKIE | TQFRRGLITE | DERYRKVIGI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| WNDATDKVTK | ALMATLDKFN | NVYMMATSGA | RGNIQQIRQL | AGMRGLMADP | SGRIIDLPIK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ANFREGLTVL | EYFISTHGAR | KGLADTALRT | ADSGYLTRRL | VDVAQDVIVR | EDDCGTTEGI |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EVREIRDGTE | GIEKLHERLE | GRVPMEVVVH | PETGEVLISQ | EQVDNHQVMT | EEQAQAIEDA |
| 850 | 860 | 870 | 880 | 890 | 900 |
| GIEKVKIRSV | ITCKTRYGVC | KHCYGKNLAT | GGNIDIGEAV | GIIAAQSIGE | PGTQLTMRTF |
| 910 | 920 | 930 | 940 | 950 | 960 |
| HTGGVAGDDI | TQGLPRVEEL | FEARRPKGQA | IVAEEDGSIA | IREVKGRREI | EITKDNGEKN |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| VYAVPFGARI | KVKEGQRIEA | GDELTEGSVN | PHDLLKIKGP | AGVQVYLLQE | VQRVYRLQGV |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| EINDKHIEVM | IRQMLRKVKI | EEAGDTELLP | GGLIDIFEFE | EENRKAVEQG | GEPAVAKPVL |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| LGITKASLAT | DSFLSAASFQ | ETTRVLTEAA | IKGKMDPLLG | LKENVIIGKL | VPAGTGMSRY |
| 1150 | 1160 | 1170 | 1180 | ||
| RNIEVLEEGQ | PFLEEDRDIL | LPERDRDYNF | LSDEEKIDFD | LTLEK |