A4IQ60

PR
Gene name
panC
Protein name
Pantothenate synthetase
Names
PS, Pantoate--beta-alanine ligase, Pantoate-activating enzyme
Species
Geobacillus thermodenitrificans (strain NG80-2)
KEGG Pathway
gtn:GTNG_2112
EC number
6.3.2.1: Acid--amino-acid ligases (peptide synthases)
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

156-229 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4IQ60

Entry ID Method Resolution Chain Position Source
AF-A4IQ60-F1 Predicted AlphaFoldDB

No variants for A4IQ60

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4IQ60

No associated diseases with A4IQ60

1 regional properties for A4IQ60

Type Name Position InterPro Accession
domain Cytidyltransferase-like domain 26 - 70 IPR004821

Functions

Description
EC Number 6.3.2.1 Acid--amino-acid ligases (peptide synthases)
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
pantoate-beta-alanine ligase activity Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.

1 GO annotations of biological process

Name Definition
pantothenate biosynthetic process The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIIVDRISEM QALMRQYHRE GKTIGFVPTM GYLHEGHAAL IDRARQENDI VVLSVFVNPL
70 80 90 100 110 120
QFGPNEDFAR YPRDFERDRH IAEQHGVDVL FHPEAGEMYP GPLTVQVVVK ARTDVLCGRS
130 140 150 160 170 180
RPGHFDGVAT VLTKLFHIVM PDRAYFGLKD AQQVAVVDGL IRDFNFPIEL VPVPTVREAD
190 200 210 220 230 240
GLAKSSRNVY LSPQEREEAP ALYQALRAAA AAVDGGERSA DAIRRLVKEH IEAHTHAEID
250 260 270 280
YVEVCSYPDL APLETLHGTV LVAVAVRFAS ARLIDNIILE LPKAHRQED