A4IIZ9

PR
Gene name
med28
Protein name
Mediator of RNA polymerase II transcription subunit 28
Names
Mediator complex subunit 28
Species
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
KEGG Pathway
xtr:100125095
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-54 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4IIZ9

Entry ID Method Resolution Chain Position Source
AF-A4IIZ9-F1 Predicted AlphaFoldDB

No variants for A4IIZ9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4IIZ9

No associated diseases with A4IIZ9

No regional properties for A4IIZ9

Type Name Position InterPro Accession
No domain, repeats, and functional sites for A4IIZ9

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFSAQQPGPP PPNQPGAPAG LMSTPPGAKN PSSTLVDDLE SSFEACFASL VSQDYVNGTD
70 80 90 100 110 120
QEEIRTGVEQ CIQKFLDVAR QTECFFLQKR LQLSVQKPEQ VIKEDVSELR NELQRKEALI
130 140 150 160
QKHLTKLRSW QQVLEEINGQ HKKTSEMPQG PLAYLEQASA NIPAPMKPT