A4H452

PR
Gene name
LBRM_05_0060
Protein name
Major vault protein
Names
Species
Leishmania braziliensis
KEGG Pathway
lbz:LBRM_05_0060
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

69-138 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4H452

Entry ID Method Resolution Chain Position Source
AF-A4H452-F1 Predicted AlphaFoldDB

No variants for A4H452

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4H452

No associated diseases with A4H452

13 regional properties for A4H452

Type Name Position InterPro Accession
repeat Major vault protein, N-terminal 54 - 115 IPR002499-1
repeat Major vault protein, N-terminal 119 - 170 IPR002499-2
repeat Major vault protein, N-terminal 171 - 223 IPR002499-3
repeat Major vault protein, N-terminal 224 - 278 IPR002499-4
repeat Major vault protein, N-terminal 329 - 380 IPR002499-5
domain Major vault protein, shoulder domain 501 - 649 IPR021870
domain Major vault protein repeat domain 3 449 - 510 IPR040989
domain Major vault protein repeat domain 2 49 - 105 IPR041134
domain Major vault protein repeat domain 4 377 - 426 IPR041136
domain Major vault protein repeat domain 115 - 155 IPR041139-1
domain Major vault protein repeat domain 167 - 207 IPR041139-2
domain Major vault protein repeat domain 222 - 253 IPR041139-3
domain Major vault protein repeat domain 326 - 364 IPR041139-4

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTDSVIRIKR YYYIHILDNN TNVTRTISGP VVYTRQEHET CLFDPRPCVS VPPRHYCVVK
70 80 90 100 110 120
NPCVRNEAGE VVLESSGQVK LRLGDAEIRF EGEPFPLYPG EELDSKEEQS VRKLQVIPPN
130 140 150 160 170 180
TGLHVRCVRD FKDAERLVVA GTEWMVAGPQ SYIPRVEVAV VEEVKATVIY PNTALLLQAN
190 200 210 220 230 240
VNFTDRRGVL RVAGEKWLVR TLGAYLPSVE ETVVSLIQGT MLSELKALRL SAVRSFTDVY
250 260 270 280 290 300
GKARRAGEQW QVTLKDAPVH IVDAYETKVA EVAAVSLNAK EYVIIHHPVD ATGHNRFGET
310 320 330 340 350 360
LVRRGECTFF LQPEETMPRG VEQVLVVGKE EALLLEAVCE YHDGGGKHQP GSRWMVRGPC
370 380 390 400 410 420
EYIPANEVKL LEHRRVMALD RNEGIYVMNT TTGEVRAVIG KPYMLDSNEV LWEKHLPLAI
430 440 450 460 470 480
EELLESPNGS IKTCERNAGF VSRREKYRIV RFNVQHNAAV QIYDYRTKKP RIVLGPSLVM
490 500 510 520 530 540
LAPHEEFTVL SLSGGTPKVP NSMQSLQLFL GPRFSSDTIV VETSDHARLR LRLSYNWYFD
550 560 570 580 590 600
IDRANPSQRT FSVPDFIGDC CKTIASRVRG AVAAEDFDSF HRNSAKIIRI AVFGVDEVGE
610 620 630 640 650 660
AKKNLRFNAN DFVVTNIDVQ SAEPTDEKTR DSLQKSVQLA IEITTKSQEA AARHGNELKN
670 680 690 700 710 720
QEAKGHLERQ KLIDKIEVEN ARTKWLELQA KSEAVQASGQ SIAEAKARAE ALLIEVQSEM
730 740 750 760 770 780
QQAEMRAKAY RISAEAELQK LQQRQALELE YTQRQNEIDV AKARAAAEAE AEKVRRMVDA
790 800 810 820 830
IGRDTLVAIA RAGPEAQVKL LGSLGLKGYL ITDGNSPVNL FDAAHGMIGE PKK