AiPD: Autoinhibited Protein Database

A4GXA9

Gene name	EME2
Protein name	Probable crossover junction endonuclease EME2
Names
Species	Homo sapiens (Human)
KEGG Pathway	hsa:197342
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-80 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-80 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for A4GXA9

Entry ID	Method	Resolution	Chain	Position	Source
7F6L	X-ray	320 A	B	1-379	PDB
AF-A4GXA9-F1	Predicted				AlphaFoldDB

505 variants for A4GXA9

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA7818473 rs769743931	2	A>E		No	ClinGen ExAC TOPMed gnomAD
CA7818471 rs745897769	2	A>T		No	ClinGen ExAC TOPMed gnomAD
rs769743931 CA7818472	2	A>V		No	ClinGen ExAC TOPMed gnomAD
CA394244787 rs1362880433	4	V>I		No	ClinGen TOPMed
rs1308024354 CA394244816	5	G>A		No	ClinGen gnomAD
rs1267315833 CA394244831	6	P>L		No	ClinGen gnomAD
rs761602098 CA7818478	6	P>S		No	ClinGen ExAC gnomAD
CA7818480 rs772872930	7	G>E		No	ClinGen ExAC gnomAD
rs767116539 CA394244838 CA7818479	7	G>R		No	ClinGen ExAC TOPMed gnomAD
rs1035717487 CA276724062	8	R>K		No	ClinGen TOPMed
rs1035717487 CA276724063	8	R>T		No	ClinGen TOPMed
rs1387846643 CA394244868	9	A>T		No	ClinGen TOPMed
rs960179050 CA276724064	9	A>V		No	ClinGen gnomAD
CA276724067 rs1013828689	10	G>A		No	ClinGen TOPMed
CA276724066 rs925839946	10	G>R		No	ClinGen TOPMed
rs765773599 CA7818482	11	V>F		No	ClinGen ExAC TOPMed gnomAD
rs765773599 CA276724069	11	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1421705327 CA394244906	12	S>P		No	ClinGen gnomAD
rs1348739190 CA394244952	14	Q>*		No	ClinGen TOPMed gnomAD
rs1428519431 CA394244964	14	Q>H		No	ClinGen gnomAD
CA7818484 rs372940829	14	Q>R		No	ClinGen 1000Genomes ESP TOPMed gnomAD
rs1026922453 CA276724076	15	G>A		No	ClinGen TOPMed
rs758815748 CA7818486	15	G>R		No	ClinGen ExAC gnomAD
rs1026922453 CA394244968	15	G>V		No	ClinGen TOPMed
rs951011466 CA276724078	16	R>Q		No	ClinGen gnomAD
CA7818489 rs545268907	17	G>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA276724080 rs545268907	17	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1309498275 CA394244999	18	R>G		No	ClinGen TOPMed gnomAD
CA276724085 rs888712275	19	G>E		No	ClinGen TOPMed
CA7818494 rs376006516	20	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs756428652 CA7818495	21	G>S		No	ClinGen ExAC gnomAD
rs895980944 CA276724089	23	S>R		No	ClinGen TOPMed gnomAD
CA394245073 rs1189758493	23	S>T		No	ClinGen TOPMed
CA7818496 rs779987281	26	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs1482481034 CA394245110	26	R>W		No	ClinGen gnomAD
CA7818497 rs749401933	27	R>P		No	ClinGen ExAC gnomAD
rs749401933 CA394245129	27	R>Q		No	ClinGen ExAC gnomAD
rs768515441 CA394245137	28	P>H		No	ClinGen ExAC TOPMed gnomAD
CA7818498 rs768515441	28	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1022697647 CA276724093	28	P>S		No	ClinGen TOPMed gnomAD
CA394245163 rs1294335417	31	W>*		No	ClinGen TOPMed
CA394245160 rs1175190563	31	W>L		No	ClinGen gnomAD
rs1176749917 CA394245168	32	E>Q		No	ClinGen TOPMed gnomAD
CA394245200 rs1334303426	34	S>L		No	ClinGen TOPMed
rs200988728 CA7818499	35	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs747889912 CA7818500	35	D>V		No	ClinGen ExAC TOPMed gnomAD
CA276724096 rs903468782	36	S>P		No	ClinGen Ensembl
CA7818503 rs760238431	37	D>N		No	ClinGen ExAC gnomAD
CA394245239 rs1422552957	38	A>S		No	ClinGen gnomAD
CA394245260 rs1367365607	40	D>H		No	ClinGen gnomAD
CA394245259 rs1367365607	40	D>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1411305061 CA394245277	41	S>F		No	ClinGen gnomAD
CA394245289 rs572288415	43	G>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs572288415 CA7818507	43	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs572288415 CA394245291	43	G>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1264097531 CA394245304	44	S>L		No	ClinGen gnomAD
rs762453887 CA7818509	45	E>K		No	ClinGen ExAC gnomAD
CA276724103 rs531772673	48	A>G		No	ClinGen TOPMed gnomAD
rs767992290 CA7818511	50	A>G		No	ClinGen ExAC TOPMed gnomAD
CA394245353 rs1449539615	50	A>P		No	ClinGen TOPMed gnomAD
rs767992290 CA7818510	50	A>V		No	ClinGen ExAC TOPMed gnomAD
CA7818513 rs756235023	54	A>E		No	ClinGen ExAC
rs756235023 CA394245394	54	A>V		No	ClinGen ExAC
CA276724108 rs541267274	55	G>S		No	ClinGen 1000Genomes TOPMed gnomAD
rs1338015875 CA394245410	56	E>*		No	ClinGen TOPMed
rs755072652 CA7818516	57	R>L		No	ClinGen ExAC gnomAD
CA394245425 rs755072652	57	R>P		No	ClinGen ExAC gnomAD
TCGA novel	58	R>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1318785658 CA394245434	58	R>K		No	ClinGen gnomAD
CA394245437 rs1567226419	58	R>S		No	ClinGen Ensembl
CA7818518 rs779012573	59	A>E		No	ClinGen ExAC gnomAD
rs1301825887 CA394245452	60	A>V		No	ClinGen TOPMed
CA7818519 rs748045808	62	E>K		No	ClinGen ExAC gnomAD
rs1221384776 CA394245479	63	A>V		No	ClinGen gnomAD
CA394245493 rs1327505126	65	R>Q		No	ClinGen TOPMed
CA276724113 rs921366795	67	L>P		No	ClinGen TOPMed gnomAD
rs1220228144 CA394245514	68	R>W		No	ClinGen TOPMed gnomAD
rs1012970017 CA276724115	69	P>L		No	ClinGen gnomAD
rs1273413326 CA394245528	70	E>K		No	ClinGen TOPMed gnomAD
rs776373222 CA7818525	71	Q>*		No	ClinGen ExAC gnomAD
CA7818526 rs776373222	71	Q>K		No	ClinGen ExAC gnomAD
CA7818528 rs201717218	71	Q>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
RCV000968720 rs201717218 CA7818527	71	Q>R		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA7818530 rs768153832	72	V>I		No	ClinGen ExAC gnomAD
rs1322995443 CA394245560	73	L>P		No	ClinGen TOPMed gnomAD
CA7818533 rs766464153	73	L>V		No	ClinGen ExAC gnomAD
rs1304274992 CA394245571	74	K>N		No	ClinGen gnomAD
rs1439224370 CA394245568	74	K>R		No	ClinGen gnomAD
rs1350314476 CA394245574	75	R>C		No	ClinGen TOPMed gnomAD
rs1350314476 CA394245573	75	R>G		No	ClinGen TOPMed gnomAD
CA394245579 rs1408354597	75	R>L		No	ClinGen gnomAD
CA394245582 rs755233857	76	L>F		No	ClinGen ExAC TOPMed gnomAD
CA7818535 rs755233857	76	L>V		No	ClinGen ExAC TOPMed gnomAD
CA394245590 rs1278823254	77	A>T		No	ClinGen TOPMed
CA7818538 rs202231563	77	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA394245604 rs1244545020	78	V>G		No	ClinGen gnomAD
CA7818539 rs190213042 RCV000969663	79	C>F		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs190213042 CA7818541	79	C>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7818540 rs190213042	79	C>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7818542 rs780894847	80	V>G		No	ClinGen ExAC TOPMed gnomAD
rs1019240163 CA276724125	80	V>M		No	ClinGen TOPMed
rs1567226501 CA394245629	81	D>V		No	ClinGen Ensembl
CA394245641 rs1184111393	83	A>P		No	ClinGen gnomAD
CA7818566 rs768190872	84	I>T		No	ClinGen ExAC gnomAD
CA394245719 rs924742128	85	L>P		No	ClinGen TOPMed gnomAD
CA276724208 rs924742128	85	L>R		No	ClinGen TOPMed gnomAD
CA7818567 rs773774708	86	E>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA394245732 rs773774708	86	E>V		No	ClinGen ExAC TOPMed gnomAD
CA394245752 rs1245345231	87	D>E		No	ClinGen Ensembl
CA7818569 rs771398630	87	D>N		No	ClinGen ExAC TOPMed gnomAD
CA394245756 rs1161039509	88	A>T		No	ClinGen TOPMed
rs776920899 CA7818570	88	A>V		No	ClinGen ExAC gnomAD
rs765401210 CA7818572	89	G>D	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA7818571 rs759897366	89	G>S		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	91	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1383391226 CA394245815	92	V>L		No	ClinGen TOPMed gnomAD
CA394245832 rs1481587740	93	L>P		No	ClinGen TOPMed
rs1481587740 CA394245830	93	L>Q		No	ClinGen TOPMed
rs201737681 CA394245861 CA7818577	94	M>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs751652697 CA394245909	97	L>V		No	ClinGen ExAC TOPMed gnomAD
CA276724216 rs920676787	99	A>T		No	ClinGen TOPMed gnomAD
CA276724218 rs945752344	101	G>R		No	ClinGen TOPMed
rs761755726 CA7818579	102	C>Y		No	ClinGen ExAC gnomAD
CA394246018 rs1207009155	103	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA394246019 rs1207009155	103	E>Q		No	ClinGen gnomAD
CA394246059 rs1040041297	105	R>L		No	ClinGen TOPMed gnomAD
CA276724222 rs1040041297	105	R>P		No	ClinGen TOPMed gnomAD
rs750205139 CA7818581	107	E>V		No	ClinGen ExAC gnomAD
rs1409271541 CA394246098	108	P>H		No	ClinGen gnomAD
CA394246091 rs1158024218	108	P>T		No	ClinGen TOPMed gnomAD
rs1454986127 CA394246102	109	Q>*		No	ClinGen gnomAD
CA7818582 rs755997861	110	R>G		No	ClinGen ExAC gnomAD
CA7818583 rs780043716	110	R>L		No	ClinGen ExAC TOPMed gnomAD
rs886910511 CA276724224	111	P>R		No	ClinGen gnomAD
rs1385076349 CA394246128	111	P>S		No	ClinGen gnomAD
CA394246132 rs1408963552	112	A>S		No	ClinGen gnomAD
CA7818585 rs754653019	113	R>C		No	ClinGen ExAC TOPMed gnomAD
CA394246156 rs1370784928	114	S>N		No	ClinGen TOPMed
CA276724227 rs1040947078	115	L>V		No	ClinGen gnomAD
CA394246180 rs1261388776	116	R>Q		No	ClinGen gnomAD
rs778471994 CA7818586	118	T>I		No	ClinGen ExAC gnomAD
CA394246220 rs1271652829	119	R>P	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA394246218 rs1271652829	119	R>Q		No	ClinGen TOPMed gnomAD
CA276724229 rs901114865	120	A>E		No	ClinGen Ensembl
TCGA novel	120	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA276724230 rs755542062	121	S>G		No	ClinGen TOPMed gnomAD
rs996083815 CA394246239	121	S>I		No	ClinGen TOPMed gnomAD
rs996083815 CA276724232	121	S>N		No	ClinGen TOPMed gnomAD
CA394246585 rs1401312006	122	P>T		No	ClinGen gnomAD
CA7818588 rs573283501	124	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA276724630 rs781684913	124	P>L		No	ClinGen ExAC TOPMed gnomAD
CA7818589 rs781684913	124	P>R		No	ClinGen ExAC TOPMed gnomAD
CA7818587 rs573283501	124	P>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs746179767 CA7818590	125	C>*		No	ClinGen ExAC gnomAD
CA394246660 rs1455916024	126	P>L		No	ClinGen gnomAD
rs1484312352 CA394246658	126	P>S		No	ClinGen TOPMed
rs770118349 CA7818591	127	R>C		No	ClinGen ExAC TOPMed gnomAD
rs547679861 CA7818592	128	S>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA394246692 rs1318845660	128	S>T		No	ClinGen TOPMed
CA276724792 rs370257315	129	L>V		No	ClinGen ESP TOPMed gnomAD
CA7818611 rs780342111	130	P>L		No	ClinGen ExAC gnomAD
rs1175120747 CA394246800	130	P>S		No	ClinGen gnomAD
rs1468495553 CA394246809	131	P>S		No	ClinGen gnomAD
CA7818613 rs749623654	132	E>K		No	ClinGen ExAC gnomAD
CA7818612 rs749623654	132	E>Q		No	ClinGen ExAC gnomAD
CA394246873 rs1406985271	134	W>S		No	ClinGen gnomAD
CA276724799 rs1011860303	135	A>T		No	ClinGen TOPMed gnomAD
rs775087880 CA276724801	135	A>V		No	ClinGen Ensembl
rs1489374389 CA394246898	136	A>S		No	ClinGen TOPMed
rs1287147739 CA394246905	136	A>V		No	ClinGen gnomAD
rs1364721902 CA394246937	138	E>G		No	ClinGen gnomAD
CA394246948 rs1215605939	139	Q>*		No	ClinGen TOPMed gnomAD
CA394246963 rs1301017055	139	Q>H		No	ClinGen gnomAD
CA7818614 rs774459611	140	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1288010807 CA394246997	141	L>F		No	ClinGen TOPMed
CA7818617 rs748453897	142	L>V		No	ClinGen ExAC TOPMed gnomAD
rs1263355660 CA394247024	144	L>M		No	ClinGen gnomAD
TCGA novel	148	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs952305137 CA276724813	148	E>K		No	ClinGen TOPMed gnomAD
rs760675298 CA7818620	149	E>D		No	ClinGen ExAC gnomAD
rs373671283 CA7818619	149	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1596847385 CA394247083	150	F>V		No	ClinGen Ensembl
rs776419353 CA7818622	151	L>P		No	ClinGen ExAC gnomAD
rs759279647 CA7818623	152	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1456863882 CA394247102	152	Q>R		No	ClinGen TOPMed gnomAD
rs1346966435 CA394247108	153	G>C		No	ClinGen gnomAD
rs1346966435 CA394247110	153	G>S		No	ClinGen gnomAD
CA7818625 rs752266761	155	A>T		No	ClinGen ExAC TOPMed gnomAD
CA394247127 rs1344078787	155	A>V		No	ClinGen gnomAD
CA276724820 rs953133282	156	T>A		No	ClinGen TOPMed gnomAD
rs1407117721 CA394247145	158	T>A		No	ClinGen gnomAD
CA394247148 rs1284285382	158	T>I		No	ClinGen gnomAD
CA394247149 rs1328073791	159	Q>K		No	ClinGen gnomAD
CA7818669 rs765777040	160	I>V		No	ClinGen ExAC gnomAD
rs140870700 CA7818671	162	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs547167106 CA7818672	164	T>A		No	ClinGen 1000Genomes ExAC gnomAD
CA276725373 rs777850544	165	H>N		No	ClinGen gnomAD
CA394248060 rs1170021140	165	H>Q		No	ClinGen gnomAD
CA7818675 rs751796612	165	H>R		No	ClinGen ExAC gnomAD
rs777850544 CA394248048	165	H>Y		No	ClinGen gnomAD
rs781115889 CA7818677	166	W>*		No	ClinGen ExAC gnomAD
CA394248067 rs1378717492	166	W>*		No	ClinGen TOPMed
rs757562944 CA7818676	166	W>R		No	ClinGen ExAC gnomAD
CA7818679 rs148313225	168	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA394248141 rs534678192	170	I>M		No	ClinGen 1000Genomes gnomAD
rs1229447357 CA394248154	171	S>F		No	ClinGen gnomAD
rs1055597315 CA276725412	172	P>S		No	ClinGen TOPMed
rs749277136 CA7818682	173	E>*		No	ClinGen ExAC TOPMed gnomAD
CA394248186 rs1223193210	173	E>D		No	ClinGen TOPMed gnomAD
CA7818681 rs749277136	173	E>K		No	ClinGen ExAC TOPMed gnomAD
rs772529627 CA394248215	176	A>G		No	ClinGen ExAC TOPMed gnomAD
CA7818684 rs200289185	176	A>S		No	ClinGen ExAC TOPMed gnomAD
rs200289185 CA7818685	176	A>T		No	ClinGen ExAC TOPMed gnomAD
rs772529627 CA7818686	176	A>V		No	ClinGen ExAC TOPMed gnomAD
CA394248222 rs1445777080	177	R>Q		No	ClinGen TOPMed gnomAD
rs370196251 CA7818687	177	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs781257318 CA7818688	178	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1173867417 CA394248283	181	A>V		No	ClinGen gnomAD
rs764544647 CA7818692	183	I>N		No	ClinGen ExAC gnomAD
rs764544647 CA394248310	183	I>S		No	ClinGen ExAC gnomAD
rs764544647 CA394248312	183	I>T		No	ClinGen ExAC gnomAD
CA7818694 rs757361579	184	G>E		No	ClinGen ExAC TOPMed gnomAD
CA276725441 rs374046300	184	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
rs757361579 CA7818695	184	G>V		No	ClinGen ExAC TOPMed gnomAD
CA7818696 rs750423079	185	L>P		No	ClinGen ExAC gnomAD
CA7818699 rs749219990	186	D>N		No	ClinGen ExAC gnomAD
CA7818700 rs754966498	187	A>T		No	ClinGen ExAC gnomAD
CA394248526 rs1178682727	190	W>*		No	ClinGen gnomAD
rs1567227616 CA394248403	190	W>*		No	ClinGen Ensembl
rs755893525 CA7818761	192	R>C		No	ClinGen ExAC TOPMed gnomAD
rs141898850 CA7818762	192	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA276725592 rs772885888	194	H>P		No	ClinGen Ensembl
CA394248580 rs1401022644	194	H>Q		No	ClinGen TOPMed gnomAD
rs1596849260 CA394248570	194	H>Y		No	ClinGen Ensembl
CA394248581 rs1282982818	195	V>I		No	ClinGen gnomAD
CA7818765 rs200684848	197	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA394248615 rs369803881	197	R>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7818766 rs369803881	197	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs200684848 CA7818764	197	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs144550615 CA7818767	198	G>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs983742775 CA276725605	199	T>I		No	ClinGen TOPMed
rs769917579 CA7818770	200	Q>E		No	ClinGen ExAC gnomAD
rs1488554376 CA394248669	201	Q>*		No	ClinGen gnomAD
CA394248674 rs1469495773	201	Q>R		No	ClinGen TOPMed
CA7818772 rs762971032	202	P>L		No	ClinGen ExAC
CA394248699 rs762971032	202	P>R		No	ClinGen ExAC
rs764041136 CA7818773	203	E>Q		No	ClinGen ExAC gnomAD
CA7818775 rs148471217	204	S>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA394248729 rs1418543537	204	S>R		No	ClinGen gnomAD
CA7818778 rs750260632	205	P>L		No	ClinGen ExAC TOPMed gnomAD
rs750260632 CA7818777	205	P>R		No	ClinGen ExAC TOPMed gnomAD
CA7818776 rs200988006	205	P>S		No	ClinGen 1000Genomes ExAC gnomAD
RCV000969664 CA7818784 rs74763106	209	G>D		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs141795599 CA394248791	209	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs141795599 CA7818783	209	G>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1043855549 CA276725623	210	A>V		No	ClinGen TOPMed
CA7818787 rs781473892	211	E>*		No	ClinGen ExAC TOPMed gnomAD
CA7818786 rs781473892	211	E>K		No	ClinGen ExAC TOPMed gnomAD
rs781473892 CA394248808	211	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs143254614 CA7818789	213	A>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs143254614 CA394248833	213	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA276725637 rs377305101	214	V>F		No	ClinGen TOPMed gnomAD
CA276725635 rs377305101	214	V>I	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA394248850 rs1469772038	215	S>G		No	ClinGen gnomAD
CA7818791 rs368564414	215	S>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA276725642 rs1039552298	216	W>*		No	ClinGen TOPMed gnomAD
CA7818793 rs766315969	217	P>L		No	ClinGen ExAC TOPMed gnomAD
CA276725647 rs766315969	217	P>R		No	ClinGen ExAC TOPMed gnomAD
CA394248878 rs774634562	217	P>S		No	ClinGen ExAC gnomAD
CA7818792 rs774634562	217	P>T		No	ClinGen ExAC gnomAD
CA7818796 rs760410107	218	E>G		No	ClinGen ExAC TOPMed gnomAD
CA394248911 rs1596849482	219	V>G		No	ClinGen Ensembl
rs766246804 CA7818797	219	V>M		No	ClinGen ExAC gnomAD
CA394248920 rs1285143154	220	E>G		No	ClinGen TOPMed
CA7818799 rs146708149	221	E>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7818801 rs201528843 CA276725658	221	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs764639450 CA7818800	221	E>G		No	ClinGen ExAC gnomAD
rs146708149 CA7818798	221	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7818833 rs776221524	222	A>T		No	ClinGen ExAC gnomAD
CA394249000 rs1223066483	223	L>R		No	ClinGen gnomAD
CA276725733 rs1020721442	225	L>F		No	ClinGen gnomAD
rs769384187 CA7818835	226	L>M		No	ClinGen ExAC gnomAD
rs902663061 CA276725734	227	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
rs1003745212 CA276725738	227	Q>H		No	ClinGen TOPMed gnomAD
CA7818837 rs762631866	227	Q>R		No	ClinGen ExAC gnomAD
CA394249057 rs1567228021	229	W>*		No	ClinGen Ensembl
rs751095792 CA394249056	229	W>G		No	ClinGen ExAC TOPMed gnomAD
CA7818839 rs751095792	229	W>R		No	ClinGen ExAC TOPMed gnomAD
CA394249099 rs1200624339	233	D>N		No	ClinGen Ensembl
rs754107144 CA7818842	234	V>M		No	ClinGen ExAC TOPMed gnomAD
rs371577485 CA7818843	235	L>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA394249135 rs1364732199	236	L>P		No	ClinGen gnomAD
rs752965317 CA7818845	237	V>G		No	ClinGen ExAC gnomAD
rs758749133 CA7818846	238	A>V		No	ClinGen ExAC gnomAD
rs1349163921 CA394249176	240	W>*		No	ClinGen gnomAD
rs747113488 CA7818848	241	Q>E		No	ClinGen ExAC TOPMed gnomAD
CA276725756 rs1012508849	242	E>D		No	ClinGen TOPMed gnomAD
CA7818849 rs770734084	242	E>K		No	ClinGen ExAC gnomAD
rs1219851129 CA394249212	243	L>P		No	ClinGen gnomAD
rs370009102 CA7818851	245	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA7818850 rs200162380	245	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA276725764 rs200958056	246	H>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs150023204 CA7818853	247	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA7818856 rs773694902	248	C>R		No	ClinGen ExAC TOPMed gnomAD
CA394249273 rs1567228063	248	C>Y		No	ClinGen Ensembl
rs766989037 CA7818858	249	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA7818860 rs760190597	250	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1181546633 CA394249300	251	T>A		No	ClinGen TOPMed
rs1376309158 CA394249305	251	T>I		No	ClinGen TOPMed gnomAD
rs950591092 CA276725788	252	K>T		No	ClinGen gnomAD
CA7818862 rs765680620	253	A>V		No	ClinGen ExAC TOPMed gnomAD
rs376746938 CA394249346	255	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs376746938 CA7818864	255	A>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1359304378 CA394249351	255	A>V		No	ClinGen gnomAD
CA7818866 rs149208934	256	Q>*		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7818867 rs149208934	256	Q>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7818868 rs781167521	256	Q>R		No	ClinGen ExAC gnomAD
CA7818869 rs745799706	257	Y>H		No	ClinGen ExAC
CA394249382 rs1239518897	258	P>L		No	ClinGen TOPMed
rs376700961 CA7818872	258	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA7818871 rs376700961	258	P>T		No	ClinGen ESP ExAC TOPMed gnomAD
rs1178671189 CA394249396	259	L>P		No	ClinGen gnomAD
rs914886788 CA276725814	260	K>E		No	ClinGen Ensembl
rs769049876 CA7818919	261	Q>*		No	ClinGen ExAC gnomAD
CA394249482 rs61746608	262	Y>C		No	ClinGen Ensembl
CA276725878 rs61746608	262	Y>S		No	ClinGen Ensembl
rs372118667 CA7818920	263	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs772536820 CA394249492	263	R>L		No	ClinGen ExAC gnomAD
rs772536820 CA7818922	263	R>Q		No	ClinGen ExAC gnomAD
CA7818921 rs372118667	263	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs773395650 CA7818923	265	S>C		No	ClinGen ExAC gnomAD
rs143404253 CA7818926	266	Q>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs143404253 CA7818925	266	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1192994441 CA394249524	266	Q>H		No	ClinGen gnomAD
rs143404253 CA394249519	266	Q>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA276725884 rs986536342	266	Q>L		No	ClinGen TOPMed
rs759448836 CA7818927	267	A>V		No	ClinGen ExAC TOPMed gnomAD
rs752483998 CA7818931	269	S>F		No	ClinGen ExAC gnomAD
rs1382594801 CA394249565	270	F>C		No	ClinGen gnomAD
rs1420725834 CA394249577	271	C>Y		No	ClinGen gnomAD
rs777751524 CA7818933	272	T>I		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	273	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs540307002 CA7818934	274	G>R		No	ClinGen 1000Genomes ExAC gnomAD
rs377368785 CA7818935	275	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA276725893 rs867402075	275	R>H		No	ClinGen TOPMed gnomAD
rs867402075 CA394249619	275	R>P		No	ClinGen TOPMed gnomAD
rs745402339 CA7818938	276	W>*		No	ClinGen ExAC TOPMed gnomAD
CA7818939 rs147870863	276	W>*		No	ClinGen ESP ExAC gnomAD
CA394249624 rs780790049	276	W>G		No	ClinGen ExAC TOPMed
rs745402339 CA7818937	276	W>L		No	ClinGen ExAC TOPMed gnomAD
rs780790049 CA7818936	276	W>R		No	ClinGen ExAC TOPMed
rs772425480 CA7818942	277	A>G		No	ClinGen ExAC TOPMed
rs367926696 CA7818940	277	A>T		No	ClinGen ExAC
rs772425480 CA7818941	277	A>V		No	ClinGen ExAC TOPMed
rs765402613 CA7818947	278	A>D		No	ClinGen ExAC
rs776729688 CA7818945	278	A>P		No	ClinGen ExAC gnomAD
rs776729688 CA7818946	278	A>S		No	ClinGen ExAC gnomAD
CA394249640 rs776729688	278	A>T		No	ClinGen ExAC gnomAD
CA394249650 rs763966095	279	G>C		No	ClinGen ExAC TOPMed gnomAD
CA394249651 rs1287384268	279	G>D		No	ClinGen gnomAD
CA276725913 rs763966095	279	G>R		No	ClinGen ExAC TOPMed gnomAD
CA7818952 rs763966095	279	G>S		No	ClinGen ExAC TOPMed gnomAD
CA394249654 rs1287384268	279	G>V		No	ClinGen gnomAD
CA7818956 rs767302812	280	E>*		No	ClinGen ExAC TOPMed gnomAD
rs574208010 CA7818957	280	E>G		No	ClinGen 1000Genomes ExAC gnomAD
CA7818955 rs767302812	280	E>K		No	ClinGen ExAC TOPMed gnomAD
CA7818958 rs779686215	281	P>S		No	ClinGen ExAC TOPMed gnomAD
rs748594133 CA7818959	282	V>L		No	ClinGen ExAC gnomAD
CA7818963 rs747403307	286	G>A		No	ClinGen ExAC TOPMed gnomAD
CA7818962 rs778047850	286	G>S		No	ClinGen ExAC gnomAD
CA7818965 rs776691789	287	A>T		No	ClinGen ExAC TOPMed gnomAD
CA394250139 rs1165015989	287	A>V		No	ClinGen gnomAD
CA7818968 rs775696974	288	G>E		No	ClinGen ExAC TOPMed gnomAD
CA7818967 rs769758190	288	G>R		No	ClinGen ExAC TOPMed gnomAD
rs762924048 CA7818969	290	Q>R		No	ClinGen ExAC gnomAD
CA7818970 rs764129759	291	A>T		No	ClinGen ExAC gnomAD
CA7818971 rs114640322	291	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1230281143 CA394250174	292	A>S		No	ClinGen gnomAD
rs1175275243 CA394250186	293	W>*		No	ClinGen TOPMed
CA7818974 rs750041010	294	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA276726470 rs371450157	294	R>W		No	ClinGen ESP TOPMed gnomAD
rs202056564 CA7818975	295	R>S		No	ClinGen ExAC TOPMed gnomAD
CA394250231 rs1187445526	297	I>M		No	ClinGen TOPMed gnomAD
rs562711182 CA7818976	298	R>G		No	ClinGen 1000Genomes ExAC gnomAD
CA7818978 rs753395496	298	R>S		No	ClinGen ExAC TOPMed gnomAD
CA7818979 rs778272342	299	Q>*		No	ClinGen ExAC TOPMed gnomAD
CA394250256 rs1422503847	300	F>C		No	ClinGen TOPMed gnomAD
rs747561335 CA7818980	301	S>G		No	ClinGen ExAC gnomAD
rs199869634 CA7818982	302	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs757582244 CA7818981	302	R>W		No	ClinGen ExAC TOPMed gnomAD
CA394250287 rs1360783055	304	S>N		No	ClinGen gnomAD
rs1025604407 CA7818984	305	P>S		No	ClinGen TOPMed gnomAD
rs1477109677 CA394250310	306	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs779930109 CA7818987	307	V>M		No	ClinGen ExAC TOPMed gnomAD
CA7818989 rs768907545	308	A>P		No	ClinGen ExAC gnomAD
rs774399655 CA7818990	308	A>V		No	ClinGen ExAC TOPMed gnomAD
rs771754192 CA394250344	310	A>G		No	ClinGen ExAC TOPMed gnomAD
rs771754192 CA7818993	310	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1161346413 CA394250353	311	V>A		No	ClinGen TOPMed
rs1008242861 CA276726505	311	V>I		No	ClinGen Ensembl
CA7818994 rs773077546	312	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1476666681 CA394250370	313	T>I		No	ClinGen gnomAD
CA7818995 rs760181032	314	A>T		No	ClinGen ExAC gnomAD
CA7818997 rs766090627	315	F>S		No	ClinGen ExAC gnomAD
rs1170241246 CA394250393	316	P>A		No	ClinGen TOPMed gnomAD
rs563874572 CA394250396	316	P>L		No	ClinGen 1000Genomes gnomAD
CA276726515 rs563874572	316	P>R		No	ClinGen 1000Genomes gnomAD
rs759022450 CA394250404	317	S>F		No	ClinGen ExAC TOPMed gnomAD
rs952397000 CA276726524	317	S>P		No	ClinGen TOPMed
rs759022450 CA7819000	317	S>Y		No	ClinGen ExAC TOPMed gnomAD
CA7819004 rs150341255	318	P>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs150341255 CA7819003	318	P>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs150341255 CA7819005	318	P>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1398440531 CA394250410	318	P>T		No	ClinGen gnomAD
CA7819008 rs138047300	319	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7819009 rs138047300	319	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs149531255 CA7819010	319	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs138047300 CA276726543	319	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
RCV000958699 CA7819012 rs61753375	322	Q>*		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1219195896 CA394250443	322	Q>R		No	ClinGen TOPMed gnomAD
rs1450626661 CA394250455	323	Q>H		No	ClinGen TOPMed gnomAD
CA7819014 rs772844873	323	Q>P		No	ClinGen ExAC TOPMed gnomAD
rs772844873 CA7819013	323	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs766792983 CA7819042	324	A>T		No	ClinGen ExAC gnomAD
rs754262901 CA7819043	324	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs199593669 CA7819047	326	E>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs199593669 CA7819046	326	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA394250516 rs1342246417	327	A>T		No	ClinGen TOPMed
CA7819048 rs777777467	327	A>V		No	ClinGen ExAC gnomAD
CA394250541 rs1421864609	329	S>G		No	ClinGen gnomAD
CA394250546 rs1411817563	329	S>T		No	ClinGen Ensembl
rs528910143 CA7819051	330	T>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs1243291095 CA394250557	330	T>S		No	ClinGen TOPMed
rs769388005 CA7819054	331	E>K		No	ClinGen ExAC gnomAD
rs371199330 CA7819058	332	R>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7819057 rs371199330	332	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7819056 rs371199330	332	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7819055 rs376865399	332	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1297527486 CA394250580	333	E>*		No	ClinGen TOPMed
rs531529878 CA7819059	333	E>D		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7819060 rs201221323	334	R>C		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs777091490 CA7819061	334	R>H		No	ClinGen ExAC TOPMed gnomAD
rs777091490 CA7819062	334	R>P		No	ClinGen ExAC TOPMed gnomAD
rs534005461 CA7819066 CA7819065	335	M>I		No	ClinGen 1000Genomes ExAC gnomAD
rs571431327 CA7819064	335	M>T		No	ClinGen 1000Genomes ExAC gnomAD
rs765733601 CA7819063	335	M>V		No	ClinGen ExAC TOPMed gnomAD
CA7819068 rs146182784	338	L>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA276726747 rs146182784	338	L>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs781130749 CA7819069	339	A>S		No	ClinGen ExAC gnomAD
CA394250642 rs1483123437	340	D>E		No	ClinGen TOPMed
rs376076255 CA7819071	340	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs1256588352 CA394250648	341	L>F		No	ClinGen gnomAD
rs779770797 CA7819072	342	P>L		No	ClinGen ExAC TOPMed gnomAD
rs370392578 CA7819074	343	V>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA7819073 rs554266327	343	V>L		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs554266327 CA394250662	343	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7819076 rs142570450	344	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs1171172404 CA394250669	344	P>T		No	ClinGen gnomAD
CA276726796 rs891405159	345	P>L		No	ClinGen TOPMed
CA7819078 rs777250776	346	S>I		No	ClinGen ExAC TOPMed gnomAD
CA394250683 rs1376417135	346	S>R		No	ClinGen TOPMed gnomAD
rs1295994377 CA394250692	348	G>S		No	ClinGen gnomAD
rs556430480 CA7819081	349	G>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA7819082 rs139910310	350	R>C		No	ClinGen ESP ExAC gnomAD
rs61753376 CA7819083	350	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA276726827 rs1014201857	351	P>R		No	ClinGen TOPMed
rs764253118 CA7819085	351	P>S		No	ClinGen ExAC gnomAD
rs751607323 CA7819086	352	R>C		No	ClinGen ExAC TOPMed gnomAD
CA7819087 rs147967590	352	R>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA394250715 rs1183089812	353	R>G		No	ClinGen Ensembl
rs1489361947 CA394250719	353	R>K		No	ClinGen gnomAD
CA394250724 rs1266760904	354	V>L		No	ClinGen gnomAD
rs1266760904 CA394250722	354	V>M		No	ClinGen gnomAD
CA7819090 rs756061641	356	P>S		No	ClinGen ExAC gnomAD
CA394250748 rs1366753613	357	D>A		No	ClinGen Ensembl
rs1490041067 CA394250756	358	L>V		No	ClinGen TOPMed
rs180991359 CA394250764	359	S>P		No	ClinGen 1000Genomes ExAC gnomAD
rs180991359 CA7819092	359	S>T		No	ClinGen 1000Genomes ExAC gnomAD
CA7819093 rs147671872	360	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
rs778411986 CA7819094	360	R>H		No	ClinGen ExAC TOPMed gnomAD
CA7819096 rs747846198	361	R>C		No	ClinGen ExAC TOPMed gnomAD
rs373943596 CA7819097	361	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA7819095 rs747846198	361	R>S		No	ClinGen ExAC TOPMed gnomAD
CA394250838 rs1221833317	367	T>I		No	ClinGen TOPMed
rs1216757624 CA394250848	368	T>I		No	ClinGen gnomAD
rs775882954 CA7819101	369	A>T		No	ClinGen ExAC gnomAD
rs763246685 CA7819102	370	N>D		No	ClinGen ExAC gnomAD
rs149157689 CA276726869	371	P>A		No	ClinGen ESP ExAC gnomAD
CA394250871 rs1254189181	371	P>R		No	ClinGen gnomAD
rs149157689 CA7819103	371	P>S		No	ClinGen ESP ExAC gnomAD
rs762080590 CA7819106	373	L>F		No	ClinGen ExAC TOPMed gnomAD
CA394250892 rs1275776961	373	L>H		No	ClinGen gnomAD
rs762080590 CA394250887	373	L>V		No	ClinGen ExAC TOPMed gnomAD
CA394250895 rs1202197169	374	L>M		No	ClinGen TOPMed gnomAD
CA7819109 rs760567719	375	L>M		No	ClinGen ExAC TOPMed gnomAD
rs1174906627 CA394250905	375	L>Q		No	ClinGen TOPMed
CA7819105 rs765194746	375	L>T		No	ClinGen ExAC
rs760567719 CA7819110	375	L>V		No	ClinGen ExAC TOPMed gnomAD
CA7819112 rs143305780	377	L>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA7819114 rs765150813	378	G>D		No	ClinGen ExAC gnomAD
rs958183886 CA276726912	379	S>F		No	ClinGen TOPMed gnomAD
rs1311266231 CA394250942	379	S>P		No	ClinGen gnomAD
rs958183886 CA394250945	379	S>Y		No	ClinGen TOPMed gnomAD
CA394250951 rs1227487248	380	S>G		No	ClinGen gnomAD
CA394250948 rs1227487248	380	S>R		No	ClinGen gnomAD

No associated diseases with A4GXA9

2 regional properties for A4GXA9

Type	Name	Position	InterPro Accession
domain	ERCC4 domain	77 - 326	IPR006166
domain	Crossover junction endonuclease EME2, XPF-like nuclease domain	68 - 260	IPR047523

Functions

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

3 GO annotations of cellular component

Name	Definition
endodeoxyribonuclease complex	A protein complex which is capable of endodeoxyribonuclease activity.
Holliday junction resolvase complex	An endodeoxyribonuclease complex that resolves the 4-way DNA intermediates of a Holliday junction into two separate duplex DNA molecules. Can be branch-migration associated.
nuclear replication fork	The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.

2 GO annotations of molecular function

Name	Definition
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
endonuclease activity	Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.

4 GO annotations of biological process

Name	Definition
double-strand break repair	The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
mitotic intra-S DNA damage checkpoint signaling	A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.
replication fork processing	The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes.
resolution of meiotic recombination intermediates	The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged.

No homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins

10	20	30	40	50	60
MARVGPGRAG	VSCQGRGRGR	GGSGQRRPPT	WEISDSDAED	SAGSEAAARA	RDPAGERRAA
70	80	90	100	110	120
AEALRLLRPE	QVLKRLAVCV	DTAILEDAGA	DVLMEALEAL	GCECRIEPQR	PARSLRWTRA
130	140	150	160	170	180
SPDPCPRSLP	PEVWAAGEQE	LLLLLEPEEF	LQGVATLTQI	SGPTHWVPWI	SPETTARPHL
190	200	210	220	230	240
AVIGLDAYLW	SRQHVSRGTQ	QPESPKVAGA	EVAVSWPEVE	EALVLLQLWA	NLDVLLVASW
250	260	270	280	290	300
QELSRHVCAV	TKALAQYPLK	QYRESQAFSF	CTAGRWAAGE	PVARDGAGLQ	AAWRRQIRQF
310	320	330	340	350	360
SRVSPAVADA	VVTAFPSPRL	LQQALEACST	ERERMGLLAD	LPVPPSEGGR	PRRVGPDLSR
370
RICLFLTTAN	PDLLLDLGS