A4G9U4

PR
Gene name
rpoC
Protein name
DNA-directed RNA polymerase subunit beta'
Names
RNAP subunit beta', RNA polymerase subunit beta', Transcriptase subunit beta'
Species
Herminiimonas arsenicoxydans
KEGG Pathway
har:HEAR3172
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1360-1414 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4G9U4

Entry ID Method Resolution Chain Position Source
AF-A4G9U4-F1 Predicted AlphaFoldDB

No variants for A4G9U4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4G9U4

No associated diseases with A4G9U4

7 regional properties for A4G9U4

Type Name Position InterPro Accession
domain RNA polymerase, alpha subunit 344 - 394 IPR000722-1
domain RNA polymerase, alpha subunit 406 - 485 IPR000722-2
domain RNA polymerase, N-terminal 235 - 514 IPR006592
domain RNA polymerase Rpb1, domain 3 489 - 645 IPR007066
domain RNA polymerase Rpb1, domain 1 15 - 342 IPR007080
domain RNA polymerase Rpb1, domain 5 767 - 1317 IPR007081
domain RNA polymerase Rpb1, domain 4 675 - 764 IPR007083

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
magnesium ion binding Binding to a magnesium (Mg) ion.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKALLDLFKQ VQQNEQFDAI KIGLASPEKI RSWSYGEVKK PETINYRTFK PERDGLFCAK
70 80 90 100 110 120
IFGPIKDYEC LCGKYKRLKH RGVICEKCGV EVTLAKVRRE RMGHIELASP TAHIWFLKSL
130 140 150 160 170 180
PSRLGMVLDM TLRDIERVLY FEAYVVTDPG MTPLKRCQIM SEDDYAAKYE EFGDDFTAFM
190 200 210 220 230 240
GAEGIRELLR AIDIDRDAEM LRQELKDSKS EAKIKKYAKR LKVLEAFQRS GIKPDWMIME
250 260 270 280 290 300
VLPVLPPELR PLVPLDGGRF ATSDLNDLYR RVINRNNRLK RLMELRAPEI ITRNEKRMLQ
310 320 330 340 350 360
EAVDSLLDNG RRGKAMTGAN KRPLKSLAEM IKGKGGRFRQ NLLGKRVDYS GRSVIVVGPQ
370 380 390 400 410 420
LKLHQCGLPK LMALELFKPF IFNKLELMGL ATTIKAAKKL VEIQEPVVWD ILEDVIREHP
430 440 450 460 470 480
VMLNRAPTLH RLGIQAFEPV LIEGKAIQLH PLVCAAFNAD FDGDQMAVHV PLSIEAQMEA
490 500 510 520 530 540
RTLMLASNNI LFPSNGEPSI VPSQDIVLGL YYATREAINA KGEGMMFPDV SEVIRAYDNK
550 560 570 580 590 600
EVELATRITV RITEYPKNVE TGEFEKTVTR YETTVGRAIL SEILPKGLPF SVLNRALKKK
610 620 630 640 650 660
EISRLINLSF RKCGLRATVV FADQLLQSGF RLATRAGISI CVDDMLVPSQ KVDIIATAEG
670 680 690 700 710 720
EVKQIEQQYS SGLVTAGERY NKVVDIWGKA GDDVGKAMMD QLKVEDVTKR DGTKTTQESF
730 740 750 760 770 780
NAIYMMADSG ARGSAAQIRQ LAGMRGLMAK PDGSIIETPI TANFREGLNV LQYFISTHGA
790 800 810 820 830 840
RKGLADTALK TANSGYLTRR LVDVTQDLVV IEDDCGTSNG ASMKALVEGG EVIEALRDRI
850 860 870 880 890 900
LGRVAANDIV NPETQATLYA AGTLLDEDMV EEIERLGIDE VKVRTPLTCD TRFGLCALCY
910 920 930 940 950 960
GRDLGRGSMV NAGEAVGVIA AQSIGEPGTQ LTMRTFHIGG AASRAAVASS VEAKSNGTVR
970 980 990 1000 1010 1020
FTATMRYVTN GKGGQIVISR SGEVLITDDL GRERERHKVP YGATLIVKDG LVIKAGTALA
1030 1040 1050 1060 1070 1080
TWDPLTRPII TEYTGTVKFE NVEEGSTVAR QIDEVTGLST LVVIDAKRRG SVTKTVRPQV
1090 1100 1110 1120 1130 1140
KLLNEQGEEV KIAGTEHAVT IGFQVGALIT VKDGQQVTVG EVLARIPTES QKTRDITGGL
1150 1160 1170 1180 1190 1200
PRVAELFEAR SPKDAGMLAE VTGTVAFGKE TKGKQRLEIT DMDGNKHEFL ITKDKQVLVH
1210 1220 1230 1240 1250 1260
DGQVVNKGEM IVDGPADPQD ILRLLGIEAL ARYIVDEVQD VYRLQGVKIN DKHIEVIVRQ
1270 1280 1290 1300 1310 1320
MLRRVQVVDA GDANYIVGEQ VERSELLDEN DRVIAQGKIP ATYENVLLGI TKASLSTDSF
1330 1340 1350 1360 1370 1380
ISAASFQETT RVLTEAAIMG KRDGLRGLKE NVIVGRLIPA GTGLAFHRAR KEKESWEAEE
1390 1400 1410
RTALLQSEKA ARAAEAEAQF ADISSTPDSD TDAS