A4G2S9

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Herminiimonas arsenicoxydans
KEGG Pathway
har:HEAR0616
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

392-465 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4G2S9

Entry ID Method Resolution Chain Position Source
AF-A4G2S9-F1 Predicted AlphaFoldDB

No variants for A4G2S9

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4G2S9

No associated diseases with A4G2S9

4 regional properties for A4G2S9

Type Name Position InterPro Accession
domain DHHA1 domain 727 - 865 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 648 - 690 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 5 - 550 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 1 - 703 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKSSEIREKF LKFFESKGHT IVASSPLVPG NDPTLMFTNS GMVQFKDVFL GEDKRPYVRA
70 80 90 100 110 120
TSVQACLRAG GKHNDLENVG YTARHHTFFE MLGNWSFGDY FKRDALMWSW ELLTKVYGLP
130 140 150 160 170 180
GDKLLATVYI EDQEAYDIWT KEIGLPPERV IRIGDNKGGR YKSDNFWMMA DTGPCGPCSE
190 200 210 220 230 240
IFYDHGPHIA GGPPGSPDED GDRYIEIWNN VFMQFDMAED GTVKPLPAPC VDTGMGLERL
250 260 270 280 290 300
AAILQGVHSN YEIDTFAALI KAAGRETNTK DLTNNSLKVI ADHIRATAFL VADGVIPSNE
310 320 330 340 350 360
GRGYVQRRII RRAIRHGYKL GQKKPFFHKL VKDLVEQMGE AYPKLQADAQ RITEVLKAEE
370 380 390 400 410 420
ERFFETLANG MEILDAALAG GVKVLPGEVA FKLHDTFGFP LDLSADVCRE AGVSVDEAGF
430 440 450 460 470 480
AAAMEKQKAA GRAAGKFKME RAVEYTGAGN VFTGYENLQE DATVVGLYFE GTAVQQLKEG
490 500 510 520 530 540
QAGIVVLDTT PFYAESGGQV GDQGFVSAEG VQFGVEDTQK IKADVYGHHG VQTQGTLKVG
550 560 570 580 590 600
DKVQAAVDGA RRAATMRNHS VTHIMHKALR EVLGEHVQQK GSLVDAEKTR FDFAHNAPVT
610 620 630 640 650 660
HEQILEIEKR VNAEILANSD TQARVMDIES AQKTGAMMLF GEKYGETVRV LDIGSSRELC
670 680 690 700 710 720
GGTHVSRTGD IGLFKVVGES GVAAGVRRIE AITGANALSY FQDLEATVHS AAATLKSPPA
730 740 750 760 770 780
ELQPRLAQVL DQVKTLEREI NALKGKLASS QGDELLSQAV EIKGIKVLAA KLENADAGTL
790 800 810 820 830 840
RTTMDTLKDK LKTAAIVLAA VNDGKVSLIA GVTADATGKV KAGELVNFVA QQVGGKGGGR
850 860
ADMAQAGGTD ASGLPAALQG VAAWVAERA