A4FZA5

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
KEGG Pathway
mmq:MmarC5_1241
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

447-518 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4FZA5

Entry ID Method Resolution Chain Position Source
AF-A4FZA5-F1 Predicted AlphaFoldDB

No variants for A4FZA5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4FZA5

No associated diseases with A4FZA5

4 regional properties for A4FZA5

Type Name Position InterPro Accession
domain DHHA1 domain 766 - 884 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 687 - 730 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 63 - 587 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 59 - 743 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEINHDYRVK LFDELGFERK QCTECNQWFW TLDKDRTTCG DSPCDEYSFI GSPITSKKYT
70 80 90 100 110 120
YNEMVKEFTN FFAEKGHSPV KRSPVVAKRW RDDILLTIAS IAVFQPWVTS GLVKPVKNPL
130 140 150 160 170 180
VIAQPCIRLN DIDNVGRTGR HLTCFTMGAH HAFNSKDEYK YWTDKTVEYC FELMKRLGID
190 200 210 220 230 240
EKTVTFIESW WEGGGNAGPC YEVITHGVEL ATLVFMQYKK VGNDYEEIPL KIVDTGYGIE
250 260 270 280 290 300
RFAWASQGTP TVYESLFSEV IEKLKKDAGI PEVDEKIMAE SATLAGLMDI ENVGDLRVLR
310 320 330 340 350 360
QKVAEKIGMD VDELDKLISP LEYIYAIADH TRCLSFMFGD GIVPSNVKEG YLARLVLRKT
370 380 390 400 410 420
LRYMEKIGIS MSIKDIIAMQ LENMKEIYPE LSEMKEYIMD VLDSEEKKYI QTVNRGRGIV
430 440 450 460 470 480
ERMAVSKSEI TLDDLIELYD SNGIPPEIVK DVVDEINKKG KKTIAITVPD NFYTIVAERH
490 500 510 520 530 540
EEEKPEEVVS TKKELPELEV SETELLFFKH PTQVEFEAKV LKTVEKYVLL DKTLFYAEGG
550 560 570 580 590 600
GQKYDIGQLN GIEVSDVQKK NGIVFHKVSD ISKFKEGDTV KGTLNWENRL KLMRNHTATH
610 620 630 640 650 660
VINAAATRVL GKHIWQTGSN VDTEKGRLDI THYERISREQ VKEIERIANE IVLSKMPVNS
670 680 690 700 710 720
TFMDRNDSEQ KYGFTIYQGG VVPGDTLRII EIEGTDVEAC GGTHCSNTSE VGYIKVLKTE
730 740 750 760 770 780
RIQDGVERLE YSTGMGSVSE IAVLEDILID SAEILGIPND QLPKTVKRFF EEWKEQKKTI
790 800 810 820 830 840
EELQKKVGEL VKYELADKFE KHGDYEVLVE QVSGTPNELM SIADNLAIGN KLIVLMNEND
850 860 870 880 890
YLLCKRGENV ELSMKELIRN IGKGGGKDNL AQGKYSETKE QITEKISQIL NK