A4FZ87

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
KEGG Pathway
mmq:MmarC5_1223
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

53-175 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4FZ87

Entry ID Method Resolution Chain Position Source
AF-A4FZ87-F1 Predicted AlphaFoldDB

No variants for A4FZ87

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4FZ87

No associated diseases with A4FZ87

5 regional properties for A4FZ87

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 275 - 484 IPR002314
domain Anticodon-binding 505 - 598 IPR004154
domain Aminoacyl-tRNA synthetase, class II 223 - 498 IPR006195
domain Threonyl-tRNA synthetase, editing domain, archaea 1 - 135 IPR015011
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 503 - 597 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKTLLIHSDY LEFEAKEKTK IAEDTDVLNG KMDECLTVFI AVEKDDESDP DAVVKNAVDE
70 80 90 100 110 120
IVKTADNLKV KNVVVYPYAH LSSDLGSPAT AKEILAEIEK ELSGDYEVLR APFGWYKAFK
130 140 150 160 170 180
ISCKGHPLSE LSRKITTERK EEVKKEKVVS KFYIINGENL ELTEVNDEVI SKMEDKGLLA
190 200 210 220 230 240
LLKHELDIKE EGKDNGEPPH VKYIKEKEIC DYEPSSDAGH FRWYPKGKLI RDLLSDYVYN
250 260 270 280 290 300
LVVENGGMPV ETPVMYDLQN NAIREHADKF GERQYRFKQG NKDLMLRFAA CFGQFMMKKD
310 320 330 340 350 360
MYLLPKHMPL KLYELSTYSF RYEQRGELVG LKRLRAFTMP DMHTVCIDMK QAMEAFEDQL
370 380 390 400 410 420
WMGLKTGDDF KTPYAIIFRF TEDFFEENKE WFFGMAKEYK QKYGKDAILE ILPGRKHYWV
430 440 450 460 470 480
GKVDMAVVDS FGRPIENPTV QIDVESAERF GIVVHDGDKK VQPIILHCSP TGSVERVLCG
490 500 510 520 530 540
LLENAYLNTL ENKPPALPTW LTPIQARVIP VGDKHAEFAL EVATKLRASG IRADFDDRED
550 560 570 580 590 600
SMGKKVRNAG TDWVNYVVVI GDSEMESSKL TVTVREESEL KKAKKESLTV EELIEKITSD
610 620
VKDAPKRPLP LPMKCSVQPI FR