A4FYA3

PR
Gene name
leuS
Protein name
Leucine--tRNA ligase
Names
Leucyl-tRNA synthetase, LeuRS
Species
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
KEGG Pathway
mmq:MmarC5_0879
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-43 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4FYA3

Entry ID Method Resolution Chain Position Source
AF-A4FYA3-F1 Predicted AlphaFoldDB

No variants for A4FYA3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4FYA3

No associated diseases with A4FYA3

3 regional properties for A4FYA3

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 51 - 62 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 23 - 683 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 722 - 849 IPR013155

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDQNGVNEGT GHKSVDLIQI MDKWQKKWTE AKIFEAEHDL RDKFFITAAF PYLNGVLHAG
70 80 90 100 110 120
HLRTFTIPET IARYQRMKNK NVLWTFGFHV TGTPILGLAN QIKDRKEDII WAYNNLHNIP
130 140 150 160 170 180
MDELLKLKTP EAIVECFSKK ATEAFKRMGF SLDWRRNFKT DDKVFSKFIE WQFYKLKEMG
190 200 210 220 230 240
HITKGSHPVR YCPKCENPVE DHDLLHGEES TTVEYSLIKF TSEFDGKEII MPMATLRPET
250 260 270 280 290 300
LFGVTNAWVN PNEIYVMAKV HDEIQKLDGE DVELKYNGIW IVGKECADKL KEQDRKIEIL
310 320 330 340 350 360
KEIKGNELLG LKIKNPVTKK EVPLLPADFV EMGIGTGWVM SVPAHAPYDY VALRDLGKIE
370 380 390 400 410 420
EVGLIPLIEI EGYDKYPAKE IVEKLGVKDQ NDDELLEQAT SKIYKDEFHK GKLNENCGEY
430 440 450 460 470 480
AGISVKDIKE KLTKDYLNSN IAEIMYEFSE QKVVCRCGEK CIIKTVKGQW FINYSDENWK
490 500 510 520 530 540
KLAHECIDNM NFAPENIRQE FHNKVDWMKD KACARKKGLG TILPFDENWI IESLSDSTIY
550 560 570 580 590 600
MAYYTIARFI NEGLTPEQLI PELFEYVYLG NGNVEEITKN SNISKETIEE MRKEFLYYYP
610 620 630 640 650 660
LDWRCSAKDL IPNHLTFMIF NHVALFGREH WPRGIEINGY VTIEGKKLSK SKGPVLPVSE
670 680 690 700 710 720
VAENFGADVA RFYITTCAEL PQDADVKFKE MEKARDNLIK LYELAVSVME EEKTEKELSL
730 740 750 760 770 780
IDKWLLHKTY SSINGAETAY EEFQLRKIGL MFYELINDLR WYKRRGGENN NVLKEVVEIW
790 800 810 820 830 840
TKLLSPVTPH LCEEIWEKLG YAGFISQELY PEIKLEMVNE DLELGEEFIK SAMEDIRNIN
850 860 870 880 890 900
GVAKINPEKM YLYTADDWKY DLLEFMNENS EKNVKALIPM VMKEDKFKRH GKEVMKLINE
910 920 930 940 950
IMKIGVKKAI AEVEILENAK TFIESEFDCE VIVNGEDVKG KKKFAIPYKP AIYME