A4FW46

PR
Gene name
cbiA
Protein name
Cobyrinate a,c-diamide synthase
Names
Cobyrinic acid a,c-diamide synthetase, Ni-sirohydrochlorin a,c-diamide synthase, Ni-sirohydrochlorin a,c-diamide synthetase
Species
Methanococcus maripaludis (strain C5 / ATCC BAA-1333)
KEGG Pathway
mmq:MmarC5_0100
EC number
6.3.5.11: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

16-103 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4FW46

Entry ID Method Resolution Chain Position Source
AF-A4FW46-F1 Predicted AlphaFoldDB

No variants for A4FW46

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4FW46

No associated diseases with A4FW46

2 regional properties for A4FW46

Type Name Position InterPro Accession
domain CobQ/CobB/MinD/ParA nucleotide binding domain 4 - 184 IPR002586
domain CobB/CobQ-like glutamine amidotransferase 252 - 435 IPR011698

Functions

Description
EC Number 6.3.5.11 Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cobyrinic acid a,c-diamide synthase activity Catalysis of the conversion of cobyrinic acid to cobyrinic acid a,c-diamide via the intermediate formation of cobyrinic acid c-monoamide.

3 GO annotations of biological process

Name Definition
cobalamin biosynthetic process The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.
glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
methanogenesis The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKRVVIAGTS SMVGKTTIST GIMKALSKKN NVQPYKIGPD YIDPTYHTEA TKNKSRNLDS
70 80 90 100 110 120
FFMDEMQVRS IFKRHSKNKD INVIEGVRGL YEGISPYNDV GSTASVSKTL NAPVILLMDA
130 140 150 160 170 180
RSLTRSAAAI IKGFKSFDTE LNIKGVIFNK IRGEGHLNKL KEAVKYYDND IEIIGAIPRD
190 200 210 220 230 240
DGLSVSQRHL GLVPTPENKQ KLLERIDLWG NTVEECLDIE KIVELSDESF DFEVDEKNKE
250 260 270 280 290 300
ETLWKVEKNN SKIAVAFDES FNFYYWDNFD ALEENGAKIK FFSPLNDVEV PDCDTIYLGG
310 320 330 340 350 360
GYPELFSEKL SNNKSMIDSI RNFDGKIYGE CGGLMYLTNS IDGKEMLKLI DADAVMTPNV
370 380 390 400 410 420
QGLSYVKGTF EKDCIIGEKS KEFKAHEFHY SKLININEND FSYRINRGKG IINSMDGITS
430 440
KDGDIVGGYA HQHCIGNPYF AANLSKT