A4FNI7

PR
Gene name
secA
Protein name
Protein translocase subunit SecA
Names
Species
Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)
KEGG Pathway
sen:SACE_6442
EC number
7.4.2.8: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

805-953 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4FNI7

Entry ID Method Resolution Chain Position Source
AF-A4FNI7-F1 Predicted AlphaFoldDB

No variants for A4FNI7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4FNI7

No associated diseases with A4FNI7

8 regional properties for A4FNI7

Type Name Position InterPro Accession
domain Helicase, C-terminal 413 - 618 IPR001650
domain SecA DEAD-like, N-terminal 3 - 381 IPR011115
domain SecA Wing/Scaffold 611 - 827 IPR011116
domain SecA, preprotein cross-linking domain 225 - 337 IPR011130
domain Helicase superfamily 1/2, ATP-binding domain 86 - 244 IPR014001
domain SecA motor DEAD 1 - 613 IPR014018
conserved_site SecA conserved site 479 - 494 IPR020937
domain SecA, C-terminal helicase domain 399 - 583 IPR044722

Functions

Description
EC Number 7.4.2.8 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cytoplasm
  • Distribution is 50-50
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein-exporting ATPase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) -> ADP + phosphate + protein+(out); drives the concomitant secretion of proteins.

3 GO annotations of biological process

Name Definition
intracellular protein transmembrane transport The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.
protein import The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event.
protein targeting The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVLSRLLRAG EGKLLKRLRR IAAHINELED DVLALSDAEL RAKTDEFKRR HTDGESLDEL
70 80 90 100 110 120
LPEAFAVARE GARRTLGQRH FDVQLMGGAA LHLGQIAEMK TGEGKTLTCV LPAYLNAIAG
130 140 150 160 170 180
RGVHVVTVND YLAKRDADWM GRVHRFLGLE VGAIMADMTP EQRRHAYAAD ITYGTNNEFG
190 200 210 220 230 240
FDYLRDNMAW SLADCVQRGH FFSIVDEVDS ILIDEARTPL IISGPADQSS RWYQEFARLA
250 260 270 280 290 300
PMLKKDQHYE VDERKRTVGV TEDGVTIIED QLGIENLYEA ANTPLVGYLN NALKAKELYK
310 320 330 340 350 360
RDKDYIVRNG EVVIVDEFTG RILHGRRYNE GMHQAIEAKE GVEIKAENQT LATITLQNYF
370 380 390 400 410 420
RLYEKLAGMT GTAETEAAEF NGTYKLGVVP IPTNRPMARA DQPDLVYKSE VAKFEAVAED
430 440 450 460 470 480
IEEKHRKGQP VLVGTTSVER SEYLAKLLVK KGVPHNVLNA KYHQSEAAII AEAGRKGAVT
490 500 510 520 530 540
VATNMAGRGT DIVLGGNVDH LADAELRKRG LDPVDNREEY EAQWPAVVEK IKEQVEAEAE
550 560 570 580 590 600
EVRELGGLYV LGTERHESRR IDNQLRGRSG RQGDPGESRF YLSLGDELMR RFNAAMVETV
610 620 630 640 650 660
MTRLKVPDDV PIEHKMVTRA IRSAQTQVEQ QNMEIRKNVL KYDEVMNQQR SVIYDERRRV
670 680 690 700 710 720
LEGEDLQEQV RHMIRDVVTE YVNAATADGY AEDWDFEKLW SALKTLYPVS VSWEALVDSD
730 740 750 760 770 780
EDLSKERLLE EVLADAEAAY AKREAEVDGK VGPGAMRELE RRVVLSVLDR KWREHLYEMD
790 800 810 820 830 840
YLKEGIGLRA MAQRDPLVEY RREGFDMFHA MLDALKEESV GFLFNVQVEA AEPEPAPEQP
850 860 870 880 890 900
SVPVSVSRSA EPTPDLQAAA EAAAAQSQVR RAKPTSAGPA LSQLPGSTTQ APSALRGKGL
910 920 930 940 950
DAPEKQRLNY SGPTEQGGVQ TTSESAGEQG NGTSTRRERR AAARAEAKKN KRR