A4FBD3

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)
KEGG Pathway
sen:SACE_2052
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

392-479 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4FBD3

Entry ID Method Resolution Chain Position Source
AF-A4FBD3-F1 Predicted AlphaFoldDB

No variants for A4FBD3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4FBD3

No associated diseases with A4FBD3

4 regional properties for A4FBD3

Type Name Position InterPro Accession
domain DHHA1 domain 746 - 880 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 661 - 704 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 5 - 564 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 1 - 717 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQTHEINQRF TEHFRKAGHT VVPSASLILD DPTLLFVNAG MVQFKPYFLG DAPAPYPRAT
70 80 90 100 110 120
SIQKCVRTGD IDEVGKTTRH NTFFQMAGNF SFGDYFKEGA MEHAWGLLTS SQADGGYGFD
130 140 150 160 170 180
PERLWVTVFE KDEEAAALWQ KVTGIPAERI QVRDAKDNYW DMGVPGPGGP CSEIYYDRGP
190 200 210 220 230 240
KYGREGGPVV DEDRYIEIWN LVFMQDIRGE LPPKEGHPPI GELPTKNIDT GMGVERVACL
250 260 270 280 290 300
LQGVENVYET DLVRPVIAKA EELSGRSYGA NHEDDVRFRV IADHARSGVM LVGDGVTPGN
310 320 330 340 350 360
EARGYVLRRL LRRIIRSTRL LGVHEPVLGE FAAVVRDAMA PSYPELVTEF DRIDSVMRNE
370 380 390 400 410 420
EDAFLSTLTA GSKIFDLAVA DTKKAGGTQL AGAKAFQLHD TYGFPIDLTL EMASEQGLSV
430 440 450 460 470 480
DEHGFRELMS EQRRRAKEDA KSRKSGHGDL STYRTLLDQH GTTEFLGYTD LQAQSRVLGL
490 500 510 520 530 540
LVDGVPAKSA AAGTEVELIL DRTPFYAEGG GQIADTGRLT GPGVEVEVHD VQRAVPGLFV
550 560 570 580 590 600
HRAKVTAGEL GVDTSLEAAV DSKRRHAIER SHSATHLVHA AVRSAYGKRA AQAGSLNSPG
610 620 630 640 650 660
RMRFDFTAPA AVSGAVLGGV EEEVNSYLQN DVEVQSYTTT MDRAMELGAV ALFGEKYGDQ
670 680 690 700 710 720
VRVVDMGDYS RELCGGTHVG RIGQLGVVKL VADSSVGSGV HRVEALVGMD AMRHISKEHL
730 740 750 760 770 780
LVSRLAEQFK VPAEELPERI AGVVSRLRSA EKELEQLRVA QVLQSAGELA GKGTDVHGVT
790 800 810 820 830 840
LVAEQVPDGV DGGALRALAG EVRGRLGSRP AVVALFSADG DKVSFVVGVN TPAQDLGLKA
850 860 870 880
GKLVPSFAAE VGGRGGGKPD MAQGGGSNPA GITAAIAALR TGLDQAVARG