A4F5Q5

PR
Gene name
accD (accA, accDA, SACE_0026)
Protein name
Acetyl-coenzyme A carboxylase carboxyl transferase subunits beta/alpha
Names
ACCase subunits beta/alpha, Acetyl-CoA carboxylase carboxyltransferase subunits beta/alpha
Species
Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338)
KEGG Pathway
sen:SACE_0026
EC number
2.1.3.15: Carboxy- and carbamoyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

514-568 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4F5Q5

Entry ID Method Resolution Chain Position Source
AF-A4F5Q5-F1 Predicted AlphaFoldDB

No variants for A4F5Q5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4F5Q5

No associated diseases with A4F5Q5

4 regional properties for A4F5Q5

Type Name Position InterPro Accession
domain Acetyl-coenzyme A carboxyltransferase, N-terminal 21 - 290 IPR011762
domain Acetyl-coenzyme A carboxyltransferase, C-terminal 286 - 536 IPR011763
domain Acetyl-CoA carboxylase 95 - 487 IPR034733
domain Acetyl-coA carboxylase zinc finger domain 22 - 47 IPR041010

Functions

Description
EC Number 2.1.3.15 Carboxy- and carbamoyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
acetyl-CoA carboxylase complex A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex.

4 GO annotations of molecular function

Name Definition
acetyl-CoA carboxylase activity Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
carboxyl- or carbamoyltransferase activity Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor).
zinc ion binding Binding to a zinc ion (Zn).

2 GO annotations of biological process

Name Definition
fatty acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
malonyl-CoA biosynthetic process The chemical reactions and pathways resulting in the formation of malonyl-CoA, the S-malonyl derivative of coenzyme A.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAEPARTLAQ DPRLADADQV RWTRCPNCRS LVYLRRLRRN GHVCPDCAHH MRMGVHDRIE
70 80 90 100 110 120
SLLDAGSFER FGADVAPVDV LGFTDSRPYT ERLAQAQRRS GSNEAVLCGT GTIDGAPLVV
130 140 150 160 170 180
AALDFGFLGG SVGGVTGELV ARAARTALDR RTPLVLVCAS GGARMQEGTI SLMQMAKTSQ
190 200 210 220 230 240
EVARLHEAGV LVVSIGTDPT YGGVTASFGM LGDVVVAEPG ARIGFAGPQV IRQTIRQELP
250 260 270 280 290 300
AGFQTAEYLR DAGMVDLVVP RHELRAHLAR LLRVHSGGTA APAAERGYRT RPRPAADRDA
310 320 330 340 350 360
SEVLHAARDI GRPSTSDYCA RIFEDFVELH GDRVSGDDPA VVAGIGTLGG RPVVVVGHQK
370 380 390 400 410 420
GHETAELVQR NFGMPQPAGY HKARRMMDYA ERFGFPLVTF VDTPGAHPGV DAEQRGQGTA
430 440 450 460 470 480
IAECISRMAR LKVPAVSVVT GEGGSGGALA LGVGNRVLVL ENAYYSVISP EGCSTILWGT
490 500 510 520 530 540
AERTSQAAEQ LRITAEDLLR LGVVDGVVDE PAGGAQQDHA AMASRLAAAL RASIGELSEL
550 560
DGDALLDQRR RRFDRFGDPD HSDSEVQP