A4D2B8

PR
Gene name
PMS2P1
Protein name
Putative postmeiotic segregation increased 2-like protein 1
Names
PMS2-related protein 2, Postmeiotic segregation increased 2-like protein 13, Postmeiotic segregation increased 2-like protein 6, Postmeiotic segregation increased 2-like protein 8, Postmeiotic segregation increased protein 3, hPMS3, Postmeiotic segregation increased protein 8, Putative postmeiotic segregation increased 2 pseudogene 1
Species
Homo sapiens (Human)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

145-244 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A4D2B8

Entry ID Method Resolution Chain Position Source
AF-A4D2B8-F1 Predicted AlphaFoldDB

No variants for A4D2B8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A4D2B8

No associated diseases with A4D2B8

1 regional properties for A4D2B8

Type Name Position InterPro Accession
conserved_site DNA mismatch repair, conserved site 305 - 311 IPR014762

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mismatch repair complex Any complex formed of proteins that act in mismatch repair.
MutLalpha complex A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2.

3 GO annotations of molecular function

Name Definition
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent DNA damage sensor activity A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.

3 GO annotations of biological process

Name Definition
mismatch repair A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
somatic hypermutation of immunoglobulin genes Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVTMCGGHRP ENFLHQVLTE FGEELAGEGK SEVGGGAPRS YLQVASAECW AAAPAVHVGE
70 80 90 100 110 120
PVHAGGLHTE RGADPVIGLY LVHRGGACQT PTVGNRQTPT LGIHARPRRR ATTSLLTLLL
130 140 150 160 170 180
AFGKNAVRCA LIGPGSLTSR TRPLTEPLGE KERREVFFPP RPERVEHNVE SSRWEPRRRG
190 200 210 220 230 240
ACGSRGGNFP SPRGGSGVAS LERAESSSTE PAKAIKPIDR KSVHQICSGP VVPSLSTAVK
250 260 270 280 290 300
ELVENSLDAG ATNIDLKLKD YGVDLIEVSG NGCGVEEENF EGLTLKHHTS KIQEFADLPQ
310 320 330 340 350 360
VETFGFRGEA LSSLCALSDV TISTCHVSAK VGTRLVFDHY GKIIQKTPYP HPRGMTVSVK
370 380 390 400 410 420
QLFSTLPVHH KEFQRNIKKK RACFPFAFCR DCQFPEASPA MLPVQPAELT PRSTPPHPCS
430
LEDNVITVFS SVKNGPGSSR