A3NH07

PR
Gene name
acsA
Protein name
Acetyl-coenzyme A synthetase
Names
AcCoA synthetase, Acs, Acetate--CoA ligase, Acyl-activating enzyme
Species
Burkholderia pseudomallei (strain 668)
KEGG Pathway
bpd:BURPS668_A0628
EC number
6.2.1.1: Acid--thiol ligases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-60 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A3NH07

Entry ID Method Resolution Chain Position Source
AF-A3NH07-F1 Predicted AlphaFoldDB

No variants for A3NH07

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A3NH07

No associated diseases with A3NH07

5 regional properties for A3NH07

Type Name Position InterPro Accession
domain Aconitase A/isopropylmalate dehydratase small subunit, swivel domain 700 - 827 IPR000573
domain Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain 76 - 570 IPR001030
binding_site Aconitase family, 4Fe-4S cluster binding site 435 - 451 IPR018136-1
binding_site Aconitase family, 4Fe-4S cluster binding site 501 - 514 IPR018136-2
domain Aconitase A, swivel domain 676 - 844 IPR044137

Functions

Description
EC Number 6.2.1.1 Acid--thiol ligases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
acetate-CoA ligase activity Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
AMP binding Binding to AMP, adenosine monophosphate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
acetyl-CoA biosynthetic process from acetate The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSAIESVLHE RRQFAPPAAV EKAAAISGMA AYRALAEEAE RDYEGFWARL ARETLEWRKP
70 80 90 100 110 120
FGKVLDETNA PFYKWFEDGE LNASYNCLDR HVAAGLGERV AVIFEADDGT VTRVTYADLL
130 140 150 160 170 180
ARVSRFANAL KKRGVGRGDR VVIYIPMSVE GIVAMQACAR IGATHSVVFG GFSSKSLHER
190 200 210 220 230 240
IVDVGATALV TADEQMRGGK TLPLKSIADE ALAMGGCDAV KTVVVYRRTG GNVDWHAGRD
250 260 270 280 290 300
VWMHEMVANE SDACEPEWVG AEHPLFILYT SGSTGKPKGV QHSTAGYLLW VAQTMKWTFD
310 320 330 340 350 360
WKPDDVFWCT ADIGWVTGHS YITYGPLAVG ATQVVFEGVP TYPNAGRFWK MIGDHKVTVF
370 380 390 400 410 420
YTAPTAIRSL IKAAEADDRV HPRSYDLSSL RIIGTVGEPI NPEAWIWYHK NVGQARCPIV
430 440 450 460 470 480
DTWWQTETGG HMITPLPGAT PTVPGSCTLP LPGIMAAVVD ETGQDVPNGQ GGILVVKRPW
490 500 510 520 530 540
PAMARTIWGD PERFKKSYFP EELGGRLYLA GDGTVRDKET GYFTIMGRID DVLNVSGHRL
550 560 570 580 590 600
GTMEIESALV SHELVAEAAV VGRPDDTTGE AVVAFVVLKR SRPEGEEAAA LAKTLRDWVG
610 620 630 640 650
KEIGPIAKPK DIRFGDNLPK TRSGKIMRRL LRSLAKGEAI TQDTSTLENP AILEQLAEVR