A3MZ70

PR
Gene name
metG
Protein name
Methionine--tRNA ligase
Names
Methionyl-tRNA synthetase, MetRS
Species
Actinobacillus pleuropneumoniae serotype 5b (strain L20)
KEGG Pathway
apl:APL_0352
EC number
6.1.1.10: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

514-594 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A3MZ70

Entry ID Method Resolution Chain Position Source
AF-A3MZ70-F1 Predicted AlphaFoldDB

No variants for A3MZ70

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A3MZ70

No associated diseases with A3MZ70

7 regional properties for A3MZ70

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 12 - 23 IPR001412
domain tRNA-binding domain 577 - 679 IPR002547
domain Methionyl-tRNA synthetase, beta subunit, C-terminal 536 - 679 IPR004495
domain Methionyl/Leucyl tRNA synthetase 5 - 392 IPR015413
domain Methioninyl-tRNA synthetase core domain 4 - 361 IPR033911-1
domain Methioninyl-tRNA synthetase core domain 380 - 391 IPR033911-2
domain Methionyl-tRNA synthetase, anticodon-binding domain 370 - 533 IPR041872

Functions

Description
EC Number 6.1.1.10 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
methionine-tRNA ligase activity Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSRKMLVTCA LPYANGAIHL GHMLEHIQAD IWVRFQRMRG NEIYFVCADD AHGTPIMLNA
70 80 90 100 110 120
AKQGITPEQL IEKAKADHVA DFKGFNISFD NYHSTHSEEN REITTEMYKK LRANGFIKSR
130 140 150 160 170 180
VISQLFDPEK QMFLPDRFVK GTCPKCKAED QYGDNCEVCA STYSPMDLIN PRSAISGATP
190 200 210 220 230 240
IVKESEHFFF DLPNFEGMLK EWTRSGSLQS EIANKMQEWF ESGLQQWDIS RDAPYFGFPI
250 260 270 280 290 300
PDAENKFFYV WLDAPIGYMA SFKNLCDRTG LNFDEFWKKD SETELYHFIG KDIVYFHSLF
310 320 330 340 350 360
WPAMLDGCEL RKPTNVFAHG YVTVDGVKMS KSRGTFIQAS TYLKHIDPEC LRYYYAAKLN
370 380 390 400 410 420
ERIEDLDLSL EDFVQRVNSD IVNKLVNLAS RNASFIAKRF EGKLADKLED EALFAEFIAQ
430 440 450 460 470 480
SEQIAAHYEN REFNKAIRLI MDLCDKANKY VDDKAPWVIA KQEGCDAQLQ AVCSMGIELF
490 500 510 520 530 540
RVLMSYLKPV LPQLAERAEA FLQTELTWDN IQQPLLGQNV APFKSLFSRL EKKQIDAVIE
550 560 570 580 590 600
ETKALFAAQN KEKGKQKVEN TENTAVEPIA AEITIDDFAK LDLRVAKVIS CEAVPESNKL
610 620 630 640 650 660
LKFQLDLGDH QRQVLSGIKA AYNNPEELVG RFVIMVANLA PRKMKFGVSE GMILSAGTGG
670
ADLFLLSADE GIRPGMQVK