A3MYB6

PR
Gene name
ileS
Protein name
Isoleucine--tRNA ligase
Names
Isoleucyl-tRNA synthetase, IleRS
Species
Actinobacillus pleuropneumoniae serotype 5b (strain L20)
KEGG Pathway
apl:APL_0044
EC number
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

790-868 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A3MYB6

Entry ID Method Resolution Chain Position Source
AF-A3MYB6-F1 Predicted AlphaFoldDB

No variants for A3MYB6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A3MYB6

No associated diseases with A3MYB6

1 regional properties for A3MYB6

Type Name Position InterPro Accession
domain Membrane fusion protein, biotin-lipoyl like domain 87 - 135 IPR039562

Functions

Description
EC Number 6.1.1.5 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIDYKNTLNL PETGFPMRGD LAKREPDMLK NWYDKNLYQK VRESSKGKKS FILHDGPPYA
70 80 90 100 110 120
NGNIHIGHAV NKILKDIIMK SKTALGFDTP YVPGWDCHGL PIELKVEGIV GKPNEKISAA
130 140 150 160 170 180
EFRQACRDYA KEQVEGQKAD FIRMGILGDW DNPYLTMNFD TEAHIIRTLG KVIANGHLYK
190 200 210 220 230 240
GSKPVHWCLD CGSSLAEAEV EYEDKVSPSI YVRFKAIDSA AVEAKFNAVG KGSGQISAVI
250 260 270 280 290 300
WTTTPWTLPS NKAISINPEF DYQLVQFGDE RVVLVKDLVE SVQKAVGVES VEVLGEVKGD
310 320 330 340 350 360
ALELMQFQHP FYDYSVPLIL GDHVTTDGGT GLVHTAPDHG QDDFVVSKKY NIEMAGLVAN
370 380 390 400 410 420
DGKFISSTPF FAGLGVFESN EKVLEKLKEV GALLKLERIK HSYPHCWRHK TPIIFRATPQ
430 440 450 460 470 480
WFIGMETQGL REQALGEIKS VRWIPSWGEA RIDTMVANRP DWCISRQRTW GVPMTMFVHN
490 500 510 520 530 540
ETEELHPRTL EILESVAKRV EEKGIQAWWD LDPVEVLGEE DAKNYRKVPD TLDVWFDSGS
550 560 570 580 590 600
TYASVVEARP EFNGNSTDMY LEGSDQHRGW FMSSLMLSTA TNGKAPYKQV LTHGFVVDEK
610 620 630 640 650 660
GRKMSKSLGN VIVPSEVWNK NGADILRLWV ASTDYTGEIA VSHNILNSAG ESYRRIRNTA
670 680 690 700 710 720
RFLLANLNGF DPKRDLVKPE EMIALDRWAV SCALEAQNDI KEAYDNYQFH TVVQRLMRFC
730 740 750 760 770 780
SIEMGSFYLD IIKDRQYTTK ADSLARRSCQ TALWHIAEAL VRWMAPILSF TADEIWSYLP
790 800 810 820 830 840
QVEGRSEFVF TEEFYEGLFG LTEADKLDDA YWQQILKVRA ESNRVLEQAR KDKVIGSGLE
850 860 870 880 890 900
AKVTLYANNE IRAMLEQLGN ELRFVLITSQ AIIKPLSEAD VAEGEMAGLA VKVERAEGEK
910 920 930
CPRCWHFATD IGTHTEHSSV CGRCVENVAG EGEKRSFA