A3MR17

PR
Gene name
lipA
Protein name
Lipoyl synthase
Names
Lip-syn, LS, Lipoate synthase, Lipoic acid synthase, Sulfur insertion protein LipA
Species
Burkholderia mallei (strain NCTC 10247)
KEGG Pathway
bmn:BMA10247_3186
EC number
2.8.1.8: Sulfurtransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-65 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A3MR17

Entry ID Method Resolution Chain Position Source
AF-A3MR17-F1 Predicted AlphaFoldDB

No variants for A3MR17

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A3MR17

No associated diseases with A3MR17

3 regional properties for A3MR17

Type Name Position InterPro Accession
domain Elp3/MiaA/NifB-like, radical SAM core domain 92 - 301 IPR006638
domain Radical SAM 87 - 305 IPR007197
domain Lipoyl synthase, N-terminal 40 - 81 IPR031691

Functions

Description
EC Number 2.8.1.8 Sulfurtransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
lipoate synthase activity Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl.
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
protein lipoylation The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTDLTATPAP AEPAASAYDP TAKQKAQAKT ARIPIKIVPI EKLKKPEWIR VKAATSSSRF
70 80 90 100 110 120
NEIKTILREH NLHTVCEEAS CPNIGECFGK GTATFMIMGD KCTRRCPFCD VGHGRPDPLD
130 140 150 160 170 180
ADEPKNLART IAALKLKYVV ITSVDRDDLR DGGAGHFVEC IREVREQSPA TRIEILTPDF
190 200 210 220 230 240
RGRLDRALAI LNAAPPDVMN HNLETVPRLY KEARPGSDYA HSLKLLKDFK ALHPDVATKS
250 260 270 280 290 300
GLMVGLGETT DEILQVMRDL RAHDVDMLTI GQYLQPSEHH LPVREYVHPD TFKMYEEEAY
310 320
KMGFTHAAVG AMVRSSYHAD LQAHGAGVV