A3M022

PR
Gene name
NUT1 (MED5, PICST_64197)
Protein name
Mediator of RNA polymerase II transcription subunit 5
Names
Mediator complex subunit 5
Species
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
KEGG Pathway
pic:PICST_64197
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

171-266 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A3M022

Entry ID Method Resolution Chain Position Source
AF-A3M022-F1 Predicted AlphaFoldDB

No variants for A3M022

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A3M022

No associated diseases with A3M022

No regional properties for A3M022

Type Name Position InterPro Accession
No domain, repeats, and functional sites for A3M022

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.

1 GO annotations of molecular function

Name Definition
transcription coregulator activity A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

1 GO annotations of biological process

Name Definition
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSETVSLHKL VKKAVHSKLS FKTFLGLFSQ LNTKQVVQDG EYQTEILEIV QNPRNLNDKK
70 80 90 100 110 120
ITEYKVVLAI QLSLSSSEEL KRFWGNLSKI SLVGQVDYLI RLNKILKYEY SKYDKDIVRL
130 140 150 160 170 180
LIKVQYCDYI VEVLDSFGDK KLSTEQKSLA NHIVFFASSV IEHVVVKDEA LVNDLVFQLA
190 200 210 220 230 240
TRLEGLRLSN LLDFLLLKSK NILSEDQIRL TDSSGSGEDK SSDLPTITTS LYKNLSVGSL
250 260 270 280 290 300
SSAKQETYNE TIKFLWLNKI MKSWKFADNE SIFNNFVHNF IPSSDKNKNP YLTSFELIKA
310 320 330 340 350 360
TFKGFGYAVI NNDDCYVLFN WKNFIITRIP VILSTLKFAN VNDEETLERA VLNAFNSLPD
370 380 390 400 410 420
SIVKVLTNLA SGSTKVYDLR QIFIKSLIFN RLLPPVAFQK FFPMESKITQ QVILSELAQY
430 440 450 460 470 480
NHDLNLRRKF NDKLINVNSE FTSLEESGLL ELCNSLPASL EYSYSRQIEL SNAINDIIDE
490 500 510 520 530 540
MKISREHEKL NRLLLSVMSN VQLTNILVFN SNPYVVLGKM IDYIDSENFR IDDDDENFQD
550 560 570 580 590 600
VYSYCGVLIL SIISIIEKFK IDLSTFNIKN SFALDYINNF YYRLCDDLTN QIPVNSDEED
610 620 630 640 650 660
NTIATNYNNL LIDWINALFD DSNDGLSDDL IKSISIKQIY KLIPLVYQQA ITATSIGKID
670 680 690 700 710 720
FSILTNGIDY LSQVFLIPTT VSIINWLLSE ISNKKTDAES LPVKVLSEIV KSNISSESGS
730 740 750 760 770 780
QELSSLVFKI VVNICGSNIL IALKKIKDWE NSQRIRDVVS IVTANLDSNY VEKDLSLPES
790 800 810 820 830 840
KSDININEQI KSHLVNFQQQ ADSPTPIHAF IHRFISDSKD QVLRVLLQEV TSYQKQNNEA
850 860 870 880 890 900
TKIFINLASY LVVSSSIDSV EDKKYWHGYL SNVSSSATEH KILKNSDKEF NSSMDYHYSS
910 920 930 940 950 960
IFNDASSGAS NDDDLFNDKS SKQLSSGKLL EQLRTKVNRY NNLLAKFNVI FAENQDPSSP
970 980
WHKTVNTLAD KLLDDINDLY I