A3LXQ8

PR
Gene name
HSE1 (PICST_32905)
Protein name
Class E vacuolar protein-sorting machinery protein HSE1
Names
Species
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
KEGG Pathway
pic:PICST_32905
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

163-233 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A3LXQ8

Entry ID Method Resolution Chain Position Source
AF-A3LXQ8-F1 Predicted AlphaFoldDB

No variants for A3LXQ8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A3LXQ8

No associated diseases with A3LXQ8

3 regional properties for A3LXQ8

Type Name Position InterPro Accession
domain SH3 domain 220 - 280 IPR001452
domain VHS domain 8 - 149 IPR002014
conserved_site Ubiquitin interacting motif 168 - 187 IPR003903

Functions

Description
EC Number
Subcellular Localization
  • Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
endosome membrane The lipid bilayer surrounding an endosome.

2 GO annotations of molecular function

Name Definition
phosphatidylinositol binding Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
ubiquitin binding Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.

3 GO annotations of biological process

Name Definition
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
vacuolar transport The directed movement of substances into, out of or within a vacuole.
vesicle-mediated transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MYKAKKTTDS SLESLIKRAT DETLTTNNWE YIIAVCDKVK SDPEVATKKA ITILTTRLQS
70 80 90 100 110 120
KDANVLLRTL SLIIALGENC GSRMQQEIAS EAFLKPLTKK LKEKKLHETV KVEIAKLIEQ
130 140 150 160 170 180
LHQSFKSDPS LKPMSDAYNK IKQEHPRYLE RNVPAKPEKH DVSSKTQSEE DELQRVINLS
190 200 210 220 230 240
LQEYEREQFS KSLQKPLPDP KKTSPRNANI AQEDSDDKKP EISKVRAMFD LVSHEKDELS
250 260 270 280 290 300
FRKGDLINVI EVVYRDWWRG SLPTGEVGIF PLNYVAPVYA KSSDQIEKEL QIENRLLNVE
310 320 330 340 350 360
SKKIDKVLAM LSAATNGNEN IDDEELENLY GQVSGLRSQL GHLIMKHTQR EKELKLLNEQ
370 380 390 400 410 420
LAIEDKAFHD LLDKSISSFS NRNSYISSDV VPYPTGGNGS VNSGYPAVPN AYSGYNTYNG
430 440 450 460 470
NGTPLAMQPT SLGFGNSIYA SQPQQQPPRQ VSQQMPPQDY QSYSNINSFP EVDRM