A3LWK3

PR
Gene name
LOS1 (PICST_89506)
Protein name
Exportin-T
Names
Exportin(tRNA), Karyopherin-beta, tRNA exportin
Species
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
KEGG Pathway
pic:PICST_89506
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

606-676 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A3LWK3

Entry ID Method Resolution Chain Position Source
AF-A3LWK3-F1 Predicted AlphaFoldDB

No variants for A3LWK3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A3LWK3

No associated diseases with A3LWK3

2 regional properties for A3LWK3

Type Name Position InterPro Accession
domain Exportin-1/Importin-beta-like 102 - 249 IPR013598
domain Exportin-T, C-terminal domain 318 - 988 IPR045546

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Shuttles between the nucleus and the cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
small GTPase binding Binding to a small monomeric GTPase.
tRNA binding Binding to a transfer RNA.

2 GO annotations of biological process

Name Definition
tRNA processing The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.
tRNA re-export from nucleus The directed movement from the nucleus to the cytoplasm of a tRNA that was previously exported to the cytoplasm and then imported back into the nucleus. The processes of primary tRNA export and secondary export (re-export) can be distinguished because in organisms in which tRNA splicing occurs in the cytoplasm, the export of a mature tRNA must occur by re-export.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEQQIHQAVE IAMSGTADPN LKNQAFAFIN QIKSTEDGYK SCVDILVKSG AQPVNEGLKF
70 80 90 100 110 120
FIFQVVDENI EKLSSEQLYS LNDQLFKTLS SYISNDVSDP IYLRNKFSQL FAKIFCYVYL
130 140 150 160 170 180
NIYPNFFKSL FELISSNKQI ALDYYTRIVI AIHYEIGDKF IARSRELQDR NNLLKDAIRL
190 200 210 220 230 240
NDMNALVSSW GKILQVPSNS SEVLNNQLKI VGQYINWMEI GLFISNDYMR SIFQYLNKEH
250 260 270 280 290 300
QRNETCMTLI EIISKKMKPS NKLELVGILD ITNIINSIDL SENDDLEFVE NIAKLINQVG
310 320 330 340 350 360
QELLIVLENE PTLFSSINAQ LAKLWPLIFS SLGHEYDDVS QHVFPFIQQY LLLCKKSPEL
370 380 390 400 410 420
GSLDLLSTLL NKIIIKMKFD DDANGVDDDD ETEQFSEIRS KLKNFQDTIA VLKPDLYVEA
430 440 450 460 470 480
ITIVINESLF GGDKNWRKIE LGLFELNNFS ESLRNNLINL PKSEITNSKP FQIFQEFLVK
490 500 510 520 530 540
LINSDLIINV NHPKIQIGFF DIVVKHYNFL NAQSSQQSLI LRILEIFTSP LGLFNENEKV
550 560 570 580 590 600
RLRSWYSFFR FVKLTKPSLN NTAFVENVVI KLQPLLVIKA ELPTTDEDDD VVENGNFSSQ
610 620 630 640 650 660
LYLYESIGLL ISLLSTDLMN HKIKFIDLVF QPLFNDLENC VSSSEQVKLN QPLISMQAHH
670 680 690 700 710 720
CLMALGTFAR GYDHDFQNKY SEEIRGKINN AAQVVLITLE NFPKNELIRD AARFSFARFI
730 740 750 760 770 780
PILKNQINIH LAKFVTLVLA ANNLKISELT DFLSFLGQIV HNYKDDDNIY QLLNNLLTPL
790 800 810 820 830 840
IKKIFELSSN SGEDALIPDI IRDKYQLKKA YMTFLSAIFL NHSASLFVTE TNKQEFAEVV
850 860 870 880 890 900
TSLLEYAYDL SETSVSKLAI TQLINVVNFF GNGGKIHDPE DKYANNLPPV EGIDAFLMSR
910 920 930 940 950 960
VTQLSFELPF QKQEFDLKDA QYRLIGQEIS LLLKSYQQRG GDEFLSYLSN YLTNMGLSQS
970 980 990
LMNDFGSNLV KLDARNFKKY FITFVTQLKG NK