A3LU10
Gene name |
MSH3 (PICST_59113) |
Protein name |
DNA mismatch repair protein MSH3 |
Names |
MutS protein homolog 3 |
Species |
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis) |
KEGG Pathway |
pic:PICST_59113 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A3LU10
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A3LU10-F1 | Predicted | AlphaFoldDB |
No variants for A3LU10
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A3LU10 | |||||
No associated diseases with A3LU10
4 regional properties for A3LU10
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DNA mismatch repair protein MutS, C-terminal | 785 - 982 | IPR000432 |
| domain | DNA mismatch repair protein MutS-like, N-terminal | 120 - 240 | IPR007695 |
| domain | DNA mismatch repair protein MutS, core | 415 - 768 | IPR007696 |
| domain | DNA mismatch repair protein MutS, connector domain | 257 - 391 | IPR007860 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP-dependent DNA damage sensor activity | A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis. |
| mismatched DNA binding | Binding to a double-stranded DNA region containing one or more mismatches. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| mismatch repair | A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSYRSKQASI | SRFFKSTKSN | NSAKNEPAVQ | HIPKKTGVML | KFSYNNKENV | VEGGKDTEGP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HIVGSHVELP | GQSVNSVVNS | DSIVVNSNLE | IDPKISSVLK | RKPDIDIQLK | TTKKRSKTLT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PLEKQIRELR | ESHKDKVLVI | QIGYKYKMFG | DDAKLGSKIL | DIMYIRGGDD | GTRDEFSYCS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FPDFKLHINL | KRLLTHGLKI | GVVKQLESAI | VKTVEKSSKS | SDLMKREITG | VYTRGTYMGD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EYVQSSGNSA | DTESPYYIIC | INEINQKELS | MVAVQPKTGD | IVQDTFKDGL | NRDELETRLM |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YLNPSEVIVL | SSEQPSVETL | KTIRLVASDV | QLLPRKRKGE | DEVFNGLIEF | FDSIDNGKYK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HLGDYFSVNF | SKHIQSCFYE | LINYLSEFKL | SNVFTIPDNI | SNFTNSRKYM | VLPNNTLYAL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EIFQNYTNPA | SQKGTLIWLL | NHTRTRFGNR | LLNKWVSKPL | IEKEKIEERL | LAIEDLTGDF |
| 490 | 500 | 510 | 520 | 530 | 540 |
| NNVVDALKIQ | LDKMGKSLDL | EELLMKTHYA | ATYNLDKINR | RDIYNMLDCF | QSVLESMNRF |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EKGITEFSKT | KKSPLLTNIL | LELSEMSKTT | VVSNLLNKIN | RSYVMNESKD | PEEQVTQFFN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| LDNHNWEDIR | SEFSELDKIE | KLFEEELLNI | RRVLKRPQLQ | YITNNKEPYL | IEVRNGKQVD |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ELPTDFHRIN | GTTTVSRFRS | ERTAQLYIKK | QYHKEKLLVN | CNVAFNDFLK | EIDEQYEFFS |
| 730 | 740 | 750 | 760 | 770 | 780 |
| KIVKNLSVFD | CLLSLTAASL | ASKNTRPILV | DQQLIEVQKG | RNPIIESLHN | RNDYVPNDID |
| 790 | 800 | 810 | 820 | 830 | 840 |
| ICYDNKVLII | TGPNMGGKSS | YVKQVALLVI | MSQIGCYIPC | DRATLGVFDS | IFIRMGASDN |
| 850 | 860 | 870 | 880 | 890 | 900 |
| ILKGNSTFMN | EMLECSNIIH | GISNKSLVIL | DEIGRGTGTS | DGIALAYSIL | RYLIESPLRP |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LVLFITHYPS | LHVLEDSFPT | VVTNYHMGFQ | QIHKDDNDFP | EIIFLYNLVK | GVINNSYGLN |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| VAKLAGLPVS | VISGAHRVSE | SLKYKVEIQQ | KEQFTMKFGS | ILQMLKKDEI | NSNNILELEN |
| LFSYI |