A3LSW7

PR
Gene name
MMM1
Protein name
Maintenance of mitochondrial morphology protein 1
Names
Species
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
KEGG Pathway
pic:PICST_59052
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

280-368 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A3LSW7

Entry ID Method Resolution Chain Position Source
AF-A3LSW7-F1 Predicted AlphaFoldDB

No variants for A3LSW7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A3LSW7

No associated diseases with A3LSW7

2 regional properties for A3LSW7

Type Name Position InterPro Accession
domain MMM1 domain 75 - 428 IPR019411
domain Synaptotagmin-like mitochondrial-lipid-binding domain 165 - 417 IPR031468

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum membrane ; Single-pass type I membrane protein
  • The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions
  • These foci are often found next to mtDNA nucleoids
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
ERMES complex A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles.
integral component of endoplasmic reticulum membrane The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
lipid binding Binding to a lipid.

3 GO annotations of biological process

Name Definition
lipid transport The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
mitochondrial genome maintenance The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.
protein insertion into mitochondrial outer membrane The process comprising the insertion of proteins from outside the organelle into the mitochondrial outer membrane, mediated by large outer membrane translocase complexes.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MADLETSDLS RVLPSSNLLS LEQLQEQLKR HRDELFQQQQ DSHVLGSKPD DSLNNNYLLS
70 80 90 100 110 120
HQYHDSQVYI PSNTWSFTQG LIVGQLSVVF VIVIFIKFFV FAESSPALAK SSITKDASVV
130 140 150 160 170 180
IVKRDKKDQS SSDDADPDDD SETTASNAKV AAILEKTYYD VDNHSPESLD WFNVLVAQTI
190 200 210 220 230 240
AQLRSEALLS DNIYHSLNNF LLKSELPEYL DKINLTEIDI GDDFPIFSNC RIKHSKDGSG
250 260 270 280 290 300
RLEAKIDVDL SDTLTLGIET KLLLNHPRPL TAVLPVQLSV SMVRFSGCLT VSLINTADPE
310 320 330 340 350 360
FAELSAHNSP EPGEPMSRSH SAGSPGGDSS HDEVISTPDS SSHTAQRKHS KDDPNDGTAL
370 380 390 400 410 420
MFSFSPDYRL EFTVKSLIGA RAKLQDVPKI SSLIENRLRA WFIERCIEPR FQVVRLPSLW
430 440
PRRKNTREQV TNKNGDKVED GSN