A3LS22

PR
Gene name
RRP3
Protein name
ATP-dependent rRNA helicase RRP3
Names
Species
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
KEGG Pathway
pic:PICST_57234
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-95 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A3LS22

Entry ID Method Resolution Chain Position Source
AF-A3LS22-F1 Predicted AlphaFoldDB

No variants for A3LS22

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A3LS22

No associated diseases with A3LS22

6 regional properties for A3LS22

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 219 - 227 IPR000629
domain Helicase, C-terminal 297 - 444 IPR001650
domain DEAD/DEAH box helicase domain 95 - 262 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 90 - 288 IPR014001
domain RNA helicase, DEAD-box type, Q motif 71 - 99 IPR014014
domain DDX47/Rrp3, DEAD-box helicase domain 72 - 274 IPR044765

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

1 GO annotations of biological process

Name Definition
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAIVGSNSVS KKPKHTKRND ARDLAEKIKR NALKKQEQDK KQQLEEESKP ESSQKSKNIV
70 80 90 100 110 120
EVNPDDEVKF STFSELKLVP ELLEAIQQMK FSKPTPIQSE AIPHALEGKD IIGLAQTGSG
130 140 150 160 170 180
KTAAFAIPIL QSLWEAQTPY FGLVLAPARE LAYQIKETFD ALGSTMGVRT VCLVGGMDMM
190 200 210 220 230 240
DQARDLMRKP HIIIATPGRI MDHLEHTKGF SLKMLKYFVM DEADKLLDLE FGPVLDKILK
250 260 270 280 290 300
QIPSKRTTYL FSATMTNKIE KLQRASLHNP VRVAVSSKYQ TADNLIQSMM LVSDGYKNTY
310 320 330 340 350 360
LIHLLNEFVG KSIIIFARTR AHTQRTSILC RILGFSAVPL HGDLTQAQRL GSLNKFKSGT
370 380 390 400 410 420
ANILIATDVA ARGLDIPSVD VVINYDIPTD SKAYVHRVGR TARAGRSGKS ISLVTQYDLE
430 440 450 460 470 480
MYLRIEQSIQ KKLPKDPSPP KAMLDALHVH VDRAYAEAIR QTKEFHEKTR RGRRGKDDKD
REEH