A3LRW2

PR
Gene name
DBP3 (PICST_82655)
Protein name
ATP-dependent RNA helicase DBP3
Names
Species
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
KEGG Pathway
pic:PICST_82655
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-107 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A3LRW2

Entry ID Method Resolution Chain Position Source
AF-A3LRW2-F1 Predicted AlphaFoldDB

No variants for A3LRW2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A3LRW2

No associated diseases with A3LRW2

4 regional properties for A3LRW2

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 263 - 271 IPR000629
domain Helicase, C-terminal 334 - 496 IPR001650
domain DEAD/DEAH box helicase domain 140 - 307 IPR011545
domain Helicase superfamily 1/2, ATP-binding domain 135 - 335 IPR014001

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

1 GO annotations of biological process

Name Definition
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MVEEHKNKKR RQEDGPADVP EKKVKVSKSE KKDKKEKKEK KEKKEKKEKK EKKEKKEKKE
70 80 90 100 110 120
KKKKYEHTAT ISGSAQSSQG YTQSESLTNL PQSEIDSFLA TNEVTIEDPH SLNLRPLLSF
130 140 150 160 170 180
DQIQLNSKIS AVVNKFPTPT PIQSVAWPYL LSGKDVIGVA ETGSGKTFAF GVPAINNILT
190 200 210 220 230 240
LGKSGLSVLC ISPTRELASQ IYDNLVDLTS NTNVKCVCVY GGVPKHDQVK NLKNANVVVA
250 260 270 280 290 300
TPGRLLDLIE DGAVNLGTVD YLVLDEADRM LETGFEDAIK AIIGGTKKEN RQTLMFTATW
310 320 330 340 350 360
PQEVRKLAST FMNQPVKVSI GDRDELAANK RITQIVEVIE PFDKEKKLLG LLRQYQSGSK
370 380 390 400 410 420
KNDKVLIFAL YKKEATRIEG LLRRNSYNVA AIHGDLSQQQ RTNALNSFKK GESSLLLATD
430 440 450 460 470 480
VAARGLDIPN VKVVINLTFP LTVEDYVHRI GRTGRAGQTG TAHTLFTEHE KHLSGALMNI
490 500 510 520
LRGANQPVPD ELLKFGGHTK KKAHSAYGAF FKDVDMTKTA KKIKFD