A3GFS1

PR
Gene name
NPL4 (PICST_80363)
Protein name
Nuclear protein localization protein 4
Names
Species
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
KEGG Pathway
pic:PICST_80363
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

64-144 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A3GFS1

Entry ID Method Resolution Chain Position Source
AF-A3GFS1-F1 Predicted AlphaFoldDB

No variants for A3GFS1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A3GFS1

No associated diseases with A3GFS1

3 regional properties for A3GFS1

Type Name Position InterPro Accession
domain NPL4, zinc-binding putative 122 - 265 IPR007716
domain Nuclear pore localisation protein NPL4, C-terminal 234 - 574 IPR007717
domain MPN domain 246 - 383 IPR037518

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, perinuclear region
  • Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Nucleus membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Localizes mainly at the nuclear periphery and the endoplasmic reticulum membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
nuclear membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
mRNA transport The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSVTLRFRSR EGTFRVAANP DADFLLVLEQ LLSKISIEDV QNLYLSDKPN SKGELANGLC
70 80 90 100 110 120
GKTVTELGLK NGDMLYASYE AATGSNPDST TNITTSTNNH NSGSISIGHI SIPTTTSGPR
130 140 150 160 170 180
KVTQLPVDDV LEKDEGLIKR PLTKFCRHGA KGMCEFCSPL PPWDANYRKE NAIKHMSYHA
190 200 210 220 230 240
YLKELNELKN SKHNSSSYIA PLEEPNYSIL LNCNEGHQPY PKGICSKCQP PPITLQLQKF
250 260 270 280 290 300
RMVDHVEFAT SSIMNNFIDV WRHTGVQRFG VMYGRYEPFD KVPLGIKAVV EAIYEPPQSG
310 320 330 340 350 360
ELDGITMLPW ENEAEVDAIA SELGIYKVGV VFTDLTDSGQ KNGTVLCKRH KDSYFLSNLE
370 380 390 400 410 420
ILMAARNQIQ HANITKFSSS GQFSSKFVTC VISGGLNGEI EPRSYQVSTS AEALVRADII
430 440 450 460 470 480
TGSTQPSRLY VNSSNDRRYV PDVAYSELNE YGLEVKSNAK PTFPVDFLLV SLTDSFPVNP
490 500 510 520 530 540
TPMFDTDSNF VIENRDFFNE LQNLHAVSKY LNADTSGKGT SLCNFHFLVY LKRTNILGAQ
550 560 570
EFDLLLRFVR ERQYEDYLHL VESPGWMTLI TILEQST