A3GF47

PR
Gene name
SRB8 (MED12, PICST_86078)
Protein name
Mediator of RNA polymerase II transcription subunit 12
Names
Mediator complex subunit 12
Species
Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)
KEGG Pathway
pic:PICST_86078
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1451-1539 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A3GF47

Entry ID Method Resolution Chain Position Source
AF-A3GF47-F1 Predicted AlphaFoldDB

No variants for A3GF47

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A3GF47

No associated diseases with A3GF47

1 regional properties for A3GF47

Type Name Position InterPro Accession
domain Mediator complex, subunit Med12 169 - 232 IPR019035

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.

1 GO annotations of molecular function

Name Definition
transcription coregulator activity A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

1 GO annotations of biological process

Name Definition
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSKARSRNSL LSSSNRAQFG NSTQDELLKL KFSMEKPDIG LYPLNDLDNG VDLNGDNSRS
70 80 90 100 110 120
QHTAGSGVLS GNEVTYPDYK PWKDHTALPN DKKEQEHQKL NNAAYLNKGY FETPVVANEY
130 140 150 160 170 180
YSARNLIQAT VFSSTENCNE VLKELSQHLA NAYKTRNEII NKIKYESNNF KIPPRVTLTA
190 200 210 220 230 240
SKKESWLKDL ANPDLALSKI AEKIPHGIRN KILIDAVCNK SVPINRALWF TKCVLFGELV
250 260 270 280 290 300
ALRRKHQSRM SLNSPIPQSL DINTPEKFEI HWLQEWTQQV ADYIYKFSKE SSNFNTIERK
310 320 330 340 350 360
QYYMNKMTYL LTYIQALYVE FLLDKSFFLA LIIKFLKEGL PLDPLHVSEL LSSTRSETDD
370 380 390 400 410 420
LIQESWIEDL DLNYGQRLFA LTLIKIFWND ILKFDYICKE LSETLLLNYL FISKINAYSF
430 440 450 460 470 480
KQSHVQNHKA SIPEPLRQKI LDMIGDTITY LFKFNTNVFI IPNYWMLING VLFTILLNKN
490 500 510 520 530 540
VTKTEGELDE ISKQFDLIKY RNESLILNMR NVQPSITDRA TPNSAGRRGS SIWNQSFVSA
550 560 570 580 590 600
AESTATKIDI FDNEATFINR SSDDILKIIS QLDSLKLNDE LANFLKPVTS SSALTSTAIK
610 620 630 640 650 660
GCPKWRTNLK VVLYWCITRH RNSRESSEDI LIICNFLKRK VLQTLGPTRS SSQLKAEFES
670 680 690 700 710 720
EILDIIYNIA DTNSSKVVNY DLYVLINELY QLKVLTIASY LRKLIASGIF YVAPDAEDNI
730 740 750 760 770 780
LNDNSNSLVK THLSILQNLP VINNRQCDSI LKKWTSTGFN FKEKFEMGQE ILKRELIDRI
790 800 810 820 830 840
VNNTFDDQFE SHIVYVKDLN VGLKFLLVNW VTNELKSAIT ESPKLIHINP LIISNLFNFY
850 860 870 880 890 900
SICDNLTVFF KVLVKFILKN EGGMIIFYLE SLYLIARLII KHFKLVKFIA GNSYGSNSTA
910 920 930 940 950 960
YELFKLIIQN YKDCKTREFD YFKFDQVWNF IDTAVESNYS SDKNTDSRSS GKRSGIFNKE
970 980 990 1000 1010 1020
QFDSPMKINT SENVIAKMED RYTSADFRND LDLLLESTFQ PMDSNEVSEV VATLKLEFEE
1030 1040 1050 1060 1070 1080
NEMKSHRNVV PKVLDLLKSN LTEESEGLAA KLLINSQYLI KSDDVNAFDK LVQDYILELV
1090 1100 1110 1120 1130 1140
KSDMEILLVA KFLKKLIVHE IIRINDLFAF FEPIAEDPAF RVKLKALMFD LVIGLSDEER
1150 1160 1170 1180 1190 1200
EYLSNSQILQ LEIMRQWYRE RSTSSFLVLI LKGIKTIEGS IFDCPLMEKY GSSIFRILNA
1210 1220 1230 1240 1250 1260
LIVANTKLLS DELISKISTE DSIRLLSTLN NENFTPINSL QDLERIASEV DEFNLPIFQL
1270 1280 1290 1300 1310 1320
LLRVLTIKEL SPLQENEIQE RLKVLLESFL ENLSFGFTPM NSYFGELFIY LPWEYVVSIL
1330 1340 1350 1360 1370 1380
GMLEDKFLCS TTFNFDQWDN DKSVLSLTNS VGNTNLLPVF NDYFKKFSSS SSNVVESSSS
1390 1400 1410 1420 1430 1440
FFQALSKFLS KLLLIVNSDN CLEDTFEDTS SAISIFLRIL IIHKLTLTRL IVTQDGEQFQ
1450 1460 1470 1480 1490 1500
FIKNLILLIN SKFIAEGNEK LRILLYDLLL LMKSSVTEEV SKQTENELSE GTSPGFGMTA
1510 1520 1530 1540 1550 1560
QSPPPVEDAS KITEPLSSAR PSSEAASFQT NPISTYDQVS SLFNLPEPTE TNPFKDYITE
1570 1580 1590 1600 1610 1620
DRVECALTLS EDELQSGGDI HGFNESNLVL ISSSNDSTFS GAFALITNPH QRPKGQPFKL
1630 1640 1650
RSFEILEGTS TTSLNDGCIN LQLFDSYTTK ENPP