A3DMR5

PR
Gene name
gltX
Protein name
Glutamate--tRNA ligase
Names
Glutamyl-tRNA synthetase, GluRS
Species
Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)
KEGG Pathway
smr:Smar_0824
EC number
6.1.1.17: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

12-113 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A3DMR5

Entry ID Method Resolution Chain Position Source
AF-A3DMR5-F1 Predicted AlphaFoldDB

No variants for A3DMR5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A3DMR5

No associated diseases with A3DMR5

2 regional properties for A3DMR5

Type Name Position InterPro Accession
domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain 87 - 393 IPR020058
domain Glutamyl/glutaminyl-tRNA synthetase, class Ib, anti-codon binding domain 398 - 552 IPR020059

Functions

Description
EC Number 6.1.1.17 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glutamate-tRNA ligase activity Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).

1 GO annotations of biological process

Name Definition
glutamyl-tRNA aminoacylation The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. The glutamyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamic acid-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLNAYKHSGK AELKPVISKI IAEIPEIRRH VREVIDIVRE TINEVNQLPI EKQKEIIEKN
70 80 90 100 110 120
WPELLEEKPR TEEKSLPPLP NAAKGRVVTR FAPNPDYTIH LGNARPALLS YWYAEMYEGK
130 140 150 160 170 180
MILRFEDTDP RTKAPFPEAY DRIRNDLKWL GIKWNEEYIQ SLRLPILYNA LRELIKHGGA
190 200 210 220 230 240
YVDKCSPKEF KKLRDSGKPC PHRELPPEKH LEELDRIFEG YYSEGEAVVR VKTDLSHPDP
250 260 270 280 290 300
SVRDWVAARI IDTSKTPHPI VGDKYILWPT YNLAAAIDDH LMGVTHILRA KEHVSNTIKQ
310 320 330 340 350 360
KFLYDHMGWK YPETIHFGRL SLEGVILSKS RMRKMIVEYN MEPYDDPRFG TLSGLRRRGI
370 380 390 400 410 420
VRETLWRIIK DVGINVIDAR ISYVNLAAIN RSIIDPQAKR YMAIEEALPL KLIGFNNSIE
430 440 450 460 470 480
AHVLRHPSTR ETYNYIIKPG DIVYISQKDF NIIQNKMFRL MGIGNFALTR PVFSKNYIGF
490 500 510 520 530 540
EARLISLSAK EAKQYRAPII QWVKLEQSIR VKLIIPKETN LETRILLAEK ALTNEELGNI
550 560
VQFYRIGFAR IDSKEPEEIK CIFAHE