A3DKB6

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Clostridium thermocellum)
KEGG Pathway
cth:Cthe_3200
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

17-92 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A3DKB6

Entry ID Method Resolution Chain Position Source
AF-A3DKB6-F1 Predicted AlphaFoldDB

No variants for A3DKB6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A3DKB6

No associated diseases with A3DKB6

4 regional properties for A3DKB6

Type Name Position InterPro Accession
domain DHHA1 domain 735 - 874 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 655 - 698 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 558 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 711 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEKLGLNELR ERFLKFFESK GHLRLPSFSL IPQNDPSLLL INSGMAPLKP YFTGQEEPPR
70 80 90 100 110 120
RRVTTCQKCI RTPDIENVGK TARHGTFFEM LGNFSFGDYF KNEAIPWAWE FFTEDLKIPV
130 140 150 160 170 180
ERLWVSIYED DDEAFEIWNK KVGLPPERIV RMGKDNNFWE HGTGPCGPCS EIYFDRGEDK
190 200 210 220 230 240
GCGKPDCKVG CDCDRFIEVW NLVFTQFNKE EDGSYSRLKN PNIDTGMGLE RLACVMQDVN
250 260 270 280 290 300
NLFEVDTIRR VLDYICKITG VEYGSSEKTD VSIRVITDHI RSTTMMISDG VIPSNEGRGY
310 320 330 340 350 360
VLRRLLRRAA RHGKLLGMDR PFLSDVASVV IKESKGAYPE LAERAENIKK VIRIEEEKFE
370 380 390 400 410 420
ETIDQGLVIL SKYIEETRKK GEKVISGDVV FELHGTYGFP VDLTREIAEE NGLGVDEEGF
430 440 450 460 470 480
REKMKEHQNL AREDYQSKQG SAWGDDIYSK LDKSVKTEFL GYTESEATAR VLYIIKEDQV
490 500 510 520 530 540
VDEAQKGDSV TVILDRTPFY AESGGQVGDK GLIEAEGARV KVLDCKKTND GKYLHIGEIE
550 560 570 580 590 600
EGTLRNGMEV KATIDKKRRM AIARNHTTTH LLHKALRNVL GSHVNQAGSL VEPDRLRFDF
610 620 630 640 650 660
THFSAMTPEE IKSVEDQVNE KILESIAVDI REMSIDEARK MGATALFGEK YGDVVRVVKI
670 680 690 700 710 720
GDYSIELCGG THLNVTSQAG FIKIVSESGV ASGVRRIEAL TGEAALKHFD EEEKLLRDIA
730 740 750 760 770 780
QVLKTNPSDS VKRIESLLNE IKAAQKEIEQ LRSKLVSSSL DDVLAKAVEI NGVKVVTARF
790 800 810 820 830 840
DQFDMEALRN TGDTIRNKLG SGVVVLGTGF GGKVSLVVMA TKDVVAKGIH AGNIIKEAAK
850 860 870
VAGGGGGGRP DMAQAGGKDV SKIDEALKQA VKVIESQLAG