A3CNV8

PR
Gene name
aroE
Protein name
Shikimate dehydrogenase (NADP(+))
Names
SDH
Species
Streptococcus sanguinis (strain SK36)
KEGG Pathway
ssa:SSA_1469
EC number
1.1.1.25: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

137-218 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A3CNV8

Entry ID Method Resolution Chain Position Source
AF-A3CNV8-F1 Predicted AlphaFoldDB

No variants for A3CNV8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A3CNV8

No associated diseases with A3CNV8

2 regional properties for A3CNV8

Type Name Position InterPro Accession
domain Shikimate dehydrogenase substrate binding, N-terminal 12 - 94 IPR013708
domain SDH, C-terminal 250 - 275 IPR041121

Functions

Description
EC Number 1.1.1.25 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
NADP binding Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
shikimate 3-dehydrogenase (NADP+) activity Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+.

4 GO annotations of biological process

Name Definition
aromatic amino acid family biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
cellular amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.
chorismate biosynthetic process The chemical reactions and pathways resulting in the formation of the unsymmetrical ether derived from phosphoenolpyruvate and 5-phosphoshikimic acid formed as an intermediate in the biosynthesis of aromatic amino acids and many other compounds.
shikimate metabolic process The chemical reactions and pathways involving shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid. It is an important intermediate in the biosynthesis of aromatic amino acids.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRINGHTRMA AVVAKPIKHS ISPLIHNMAF EKTGVNGVYL AWEVEAKDLQ ASIENIRRYD
70 80 90 100 110 120
MFGVNLSMPY KQEVIPYLDE LDVSARLIGA VNTVVNKNGI LVGYNTDGKG FFKSLPSFAI
130 140 150 160 170 180
RGKKMTILGA GGAATAIIAQ AALYNAEEIF VFTRQASYEK IVSKMAAISH QTKSRIQVLT
190 200 210 220 230 240
LEDADSLQDK INQSDLLVNG TSLGMDGVSM PLPEQLELPS QILVADVIYQ PFETPFLKWA
250 260 270 280
RNQNVTAVNG LGMLLYQGAE AFELWTGKPM PSQEIWQCLE ELYK