A3CLP4

PR
Gene name
ileS
Protein name
Isoleucine--tRNA ligase
Names
Isoleucyl-tRNA synthetase, IleRS
Species
Streptococcus sanguinis (strain SK36)
KEGG Pathway
ssa:SSA_0661
EC number
6.1.1.5: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

11-80 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A3CLP4

Entry ID Method Resolution Chain Position Source
AF-A3CLP4-F1 Predicted AlphaFoldDB

No variants for A3CLP4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for A3CLP4

No associated diseases with A3CLP4

4 regional properties for A3CLP4

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 57 - 68 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 27 - 634 IPR002300
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 678 - 831 IPR013155
domain Isoleucyl tRNA synthetase type 1, anticodon-binding domain 633 - 809 IPR033708

Functions

Description
EC Number 6.1.1.5 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
isoleucine-tRNA ligase activity Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+).
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
isoleucyl-tRNA aminoacylation The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKLKETLNLG KTAFPMRAGL PNKEPIWQKE WDQAKLYQRR QELNEGKPHF ILHDGPPYAN
70 80 90 100 110 120
GNIHVGHAMN KISKDIIVRS KSMAGYYAPY IPGWDTHGLP IEQVLAKQGV KRKELDLVEY
130 140 150 160 170 180
LNMCRDYALS QVEKQKEDFK RLGVSGDWEN PYVTLTPDYE AAQIRVFGEM AKKGYIYRGA
190 200 210 220 230 240
KPVYWSWSSE SALAEAEIEY HDLVSTSLYY ANRVKDGKGV LDTDTYIVVW TTTPFTITAS
250 260 270 280 290 300
RGLTVGADID YVVVQPAGES RKFVVASELL NSLSEKFGWA DVQVLATYRG QELNHIVTVH
310 320 330 340 350 360
PWDTAVDELV ILGDHVTTDS GTGIVHTAPG FGEDDYNVGV ANDLEVFVTV NERGIMMENA
370 380 390 400 410 420
GPDFAGQFYD KVAPTVIEKL GDLLLAQEEI SHSYPFDWRT KKPIIWRAVP QWFASVSKFR
430 440 450 460 470 480
QEILDEIEKV KFHSEWGKVR LYNMIRDRGD WVISRQRAWG VPLPIFYAED GTPIMTAETI
490 500 510 520 530 540
EHVAQLFEEH GSIVWWKREA KDLLPEGFTH PGSPNGEFTK ETDIMDVWFD SGSSWNGVVV
550 560 570 580 590 600
NRPELTYPAD LYLEGSDQYR GWFNSSLITS VANHGVAPYK QILSQGFALD GKGEKMSKSL
610 620 630 640 650 660
GNTIAPSDVE KQFGAEILRL WVTSVDSSND VRISMDILSQ VSETYRKIRN TLRFLIANTS
670 680 690 700 710 720
DFNPVEDAVA YEELRSVDKY MTIRFNQLVE TIRKAYADFE FLTIYKAIVN FVTVDLSAFY
730 740 750 760 770 780
LDFAKDIVYI EAAKSLERRQ MQTVFYDVLV KITKLLTPIL PHTAEEIWSY LEHEEEEFVQ
790 800 810 820 830 840
LSELPEAQTF PNQEEILDTW SAFMDFRSQA QKALEEARNE KVIGKSLEAH LTVYPNEVIK
850 860 870 880 890 900
TLLEAVNSDV AQLLIVSQLT IAEGPAPEGA LVFEDVAFVV EHAQGQVCDR CRRIDTTVQE
910 920
RSYQALVCDH CAEILEENFA QAVSEGFEAN