Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A2X7U1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2X7U1-F1 | Predicted | AlphaFoldDB |
No variants for A2X7U1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A2X7U1 | |||||
No associated diseases with A2X7U1
4 regional properties for A2X7U1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 20 - 299 | IPR000719 |
| conserved_site | Mitogen-activated protein (MAP) kinase, conserved site | 55 - 153 | IPR003527 |
| active_site | Serine/threonine-protein kinase, active site | 137 - 149 | IPR008271 |
| binding_site | Protein kinase, ATP binding site | 26 - 50 | IPR017441 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA-binding transcription factor activity, RNA polymerase II-specific | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. |
| sequence-specific DNA binding | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MESDCQFLVA | PPQPHMYYDT | AAAAVDEAQF | LRQMVAAADH | HAAAAGRGGG | DGDGGGGGGG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GGGERKRRFT | EEQVRSLETT | FHARRAKLEP | REKAELAREL | GLQPRQVAIW | FQNKRARWRS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KQIEHDYAAL | RAQYDALHAR | VESLRQEKLA | LAAQVDELRG | KLNERQDQSG | SCDGGGAEGD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DDDKRNSVMN | ASSSGLVEED | YVSCLAVPVV | DVSEDGSAAC | GGSSYEYDHH | LDYLGGGQLP |
| 250 | 260 | ||||
| DPFCGMPDLW | ETWPMVEWNA | VA |