Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A2X2K3
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A2X2K3-F1 | Predicted | AlphaFoldDB |
No variants for A2X2K3
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A2X2K3 | |||||
No associated diseases with A2X2K3
8 regional properties for A2X2K3
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 43 - 78 | IPR001680-1 |
| repeat | WD40 repeat | 116 - 156 | IPR001680-2 |
| repeat | WD40 repeat | 234 - 273 | IPR001680-3 |
| repeat | WD40 repeat | 284 - 324 | IPR001680-4 |
| repeat | WD40 repeat | 343 - 381 | IPR001680-5 |
| repeat | WD40 repeat | 385 - 439 | IPR001680-6 |
| conserved_site | Protein phosphatase 2A regulatory subunit PR55, conserved site | 116 - 130 | IPR018067-1 |
| conserved_site | Protein phosphatase 2A regulatory subunit PR55, conserved site | 243 - 257 | IPR018067-2 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| protein phosphatase type 2A complex | A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein phosphatase regulator activity | Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDPFSKSPDD | DDLRPEAEAA | RRPQPQPQPR | EWRFAQVFGE | RAAGEDVQEV | DIISAIEFDK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SGDHLATGDR | GGRVVLFERT | DSRDSASRSE | LERQDYPIAR | HPEFRYKTEF | QSHEPEFDYL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KSLEIEEKIN | KIKWCQTANN | ALFLLSTNDK | TIKYWKVQER | KVKRISVMNL | NTSQSSGNGT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TSSSSSSSSR | AILPNGGCSE | KLYNFPNNDL | LFPPGGCTSL | RLPVVVTGQD | LNLVPRCRRV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YSHAHDYHIN | SISNNSDGET | YISADDLRIN | LWNLEISNQS | FNIVDVKPAN | MEDLTEVITC |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AEFHPTHCNT | LAYSSSKGSI | RLIDLRQSAL | CDNHAKLFEE | HEAPGSRSFF | TEIIASVSDI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KFARDGRHIL | SRDYMTLKLW | DINMDSGPVA | TFQVHEYLRP | KLCDLYENDS | IFDKFECCLS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GDGLRVATGS | YSNLFRVFGC | TPGSAEATTL | EASRNPMRRQ | VANPTRPART | LTSLTRAVRR |
| 490 | 500 | 510 | 520 | ||
| GGENPGVDAN | GNSYDLSTKL | LHLAWHPTEN | SIACAAANSL | YMYYA |